TGF-β signaling networks in the tumor microenvironment
MKK Chan, JYF Chung, PCT Tang, ASW Chan, JYY Ho… - Cancer letters, 2022 - Elsevier
Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …
and pathology, especially in the progression of inflammatory diseases including cancer …
[HTML][HTML] Neuroinflammation following traumatic brain injury: take it seriously or not
R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …
socioeconomic burden. With the standardization of the treatment process, there is increasing …
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature
Cerebrovascular injury (CVI) is a common pathology caused by infections, injury, stroke,
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …
[HTML][HTML] YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2
X Wang, W Fan, N Li, Y Ma, M Yao, G Wang, S He, W Li… - Genome biology, 2023 - Springer
Background Ocular neovascularization is a leading cause of blindness. Retinal microglia
have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the …
have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the …
Adhesive and conductive hydrogel-based therapy simultaneously targeting neuroinflammation and neurofunctional damage after brain injury
L Yan, C Zhao, Y Wang, Q Qin, Z Liu, Y Hu, Z Xu… - Nano Today, 2023 - Elsevier
Traumatic brain injury (TBI) caused by mechanical injury, neuroinflammation, and
neurological degeneration is highly lethal and could result in disability and death. Here, we …
neurological degeneration is highly lethal and could result in disability and death. Here, we …
Defining the role of anti-and pro-inflammatory outcomes of interleukin-6 in mental health
M García-Juárez, A Camacho-Morales - Neuroscience, 2022 - Elsevier
Abstract Interleukin-6 (IL-6) is a major cytokine that promotes anti-and pro-inflammatory
outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL …
outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL …
[HTML][HTML] Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis
X Sun, L Ma, X Li, J Wang, Y Li, Z Huang - Frontiers in Immunology, 2022 - frontiersin.org
Inflammation plays a pivotal role in ischemia-induced retinal neovascularization. Targeting
microglia/macrophage-based neuroinflammation presents a promising therapeutic strategy …
microglia/macrophage-based neuroinflammation presents a promising therapeutic strategy …
A cost-effective, fast cooling, and efficient anti-inflammatory multilayered topological hydrogel patch for burn wound first aid
First-aid burn wound patches play an essential role in reducing mortality by preventing
hyperthermia and resisting wound infection. However, existing products still suffer from …
hyperthermia and resisting wound infection. However, existing products still suffer from …
[HTML][HTML] Glucocorticoids as regulators of macrophage-mediated tissue homeostasis
D Diaz-Jimenez, JP Kolb, JA Cidlowski - Frontiers in immunology, 2021 - frontiersin.org
Our immune system has evolved as a complex network of cells and tissues tasked with
maintaining host homeostasis. This is evident during the inflammatory responses elicited …
maintaining host homeostasis. This is evident during the inflammatory responses elicited …