Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …

Cerebrovascular injury (CVI) is a common pathology caused by infections, injury, stroke,
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …

Background Ocular neovascularization is a leading cause of blindness. Retinal microglia
have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the …

Traumatic brain injury (TBI) caused by mechanical injury, neuroinflammation, and
neurological degeneration is highly lethal and could result in disability and death. Here, we …

Abstract Interleukin-6 (IL-6) is a major cytokine that promotes anti-and pro-inflammatory
outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL …

Inflammation plays a pivotal role in ischemia-induced retinal neovascularization. Targeting
microglia/macrophage-based neuroinflammation presents a promising therapeutic strategy …

First-aid burn wound patches play an essential role in reducing mortality by preventing
hyperthermia and resisting wound infection. However, existing products still suffer from …

Our immune system has evolved as a complex network of cells and tissues tasked with
maintaining host homeostasis. This is evident during the inflammatory responses elicited …