Gene expression in individual cells is highly variable and sporadic, often resulting in the
synthesis of mRNAs and proteins in bursts. Such bursting has important consequences for …

Many cellular processes are governed by stochastic reaction events. These events do not
necessarily occur in single steps of individual molecules, and, conversely, each birth or …

Inside individual cells, expression of genes is inherently stochastic and manifests as cell-to-
cell variability or noise in protein copy numbers. Since proteins half-lives can be comparable …

Gene expression in mammalian cells is highly variable and episodic, resulting in a series of
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …

Genetically identical cell populations exhibit considerable intercellular variation in the level
of a given protein or mRNA. Both intrinsic and extrinsic sources of noise drive this variability …

What determines the average length of a queue, which stretches in front of a service station?
The answer to this question clearly depends on the average rate at which jobs arrive at the …

Gene expression has inherent stochasticity resulting from transcription's burst manners.
Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics …

Gene expression is a complicated multistep process where transcription depends on a
chromatin template that can be characterized by stochastic transitions between active and …

The entropy production rate (EPR) measures time-irreversibility in systems operating far
from equilibrium. The challenge in estimating the EPR for a continuous variable system is …

Recent experimental results indicate that, in single Escherichia coli cells, the fluctuations in
mRNA level are uncorrelated with those of protein. However, a basic two-stage model for …