The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded
as a benign condition. Recently, it has been shown that TTS may be associated with severe …

Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and
stimulate the generation of second messengers such as cyclic adenosine monophosphate …

Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

Background—Takotsubo cardiomyopathy is an acute heart failure syndrome characterized
by myocardial hypocontractility from the mid left ventricle to the apex. It is precipitated by …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

The β1-and β2-adrenergic receptors (βARs) on the surface of cardiomyocytes mediate
distinct effects on cardiac function and the development of heart failure by regulating …

This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …