Electrospray ionization mass spectrometry has been used to study protein interactions
driven by noncovalent forces. The gentleness of the electrospray ionization process allows …

The development of “soft” ionization methods in recent years has enabled substantial
progress in the mass spectrometric characterization of macromolecules, in particular …

Intrinsic disorder is a new reality that appears to penetrate every corner of modern protein
science. It is difficult to imagine that only 20 years ago the situation was completely different …

A major limitation of electrospray ionization mass spectrometry (ESI-MS) for oligonucleotide
analysis arises due to sodium adduction, a problem that increases with molecular weight …

Newcomers to the field of biopharmaceuticals require an understanding of the basic
principles and underlying methodology involved in developing protein-and nucleic acid …

Mass spectrometry (MS) has been applied to drug discovery for many years. With the advent
of new ionization techniques, MS has emerged as an important analytical tool in …

Michael Przybylski (1948–2023) was a Polymer Chemist by training and devoted nearly his
entire scientific life, almost 50 years, to mass spectrometry and its biomedical applications …

Significant advances in the area of microdialysis which allowed more effective handling of
small volumes (microliters) of samples, more efficient desalting and enhanced mass …

The present invention provides methods for the determina tion of the structure of
biomolecular targets, as Well as the site and nature of the interaction betWeen ligands and …

Assembling the work of an international panel of researchers, Mass Spectrometry of
Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field …