Inverse protein folding is challenging due to its inherent one-to-many mapping
characteristic, where numerous possible amino acid sequences can fold into a single …

Stabilizing proteins is a foundational step in protein engineering. However, the evolutionary
pressure of all extant proteins makes identifying the scarce number of mutations that will …

自然界中存在的酶拥有多种多样的功能, 它们已经被应用在工业生产和学术研究中,
但其中许多酶的性质和功能还不能完全满足应用需要, 通过改造来提升这类酶的某些特性是酶 …

Advances in deep learning models have revolutionized the study of biomolecule systems
and their mechanisms. Graph representation learning, in particular, is important for …

Protein engineering is a pivotal aspect of synthetic biology, involving the modification of
amino acids within existing protein sequences to achieve novel or enhanced functionalities …

Mutations in amino acid sequences can disrupt protein structures and functions. Accurate
and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine …

Large language models (LLMs) have garnered considerable attention for their proficiency in
tackling intricate tasks, particularly leveraging their capacities for zero-shot and in-context …

Enzymes have garnered significant attention in both research and industry due to their
unparalleled specificity and functionality, and thus opportunities remain for enhancing their …