The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …

Computational models in physiology often integrate functional and structural information
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …

Electrical waves traveling throughout the myocardium elicit muscle contractions responsible
for pumping blood throughout the body. The shape and direction of these waves depend on …

Anatomically accurate and biophysically detailed bidomain models of the human heart have
proven a powerful tool for gaining quantitative insight into the links between electrical …

Mechanistic cardiac electrophysiology models allow for personalized simulations of the
electrical activity in the heart and the ensuing electrocardiogram (ECG) on the body surface …

The most important ECG marker for the diagnosis of ischemia or infarction is a change in the
ST segment. Baseline wander is a typical artifact that corrupts the recorded ECG and can …

Electromechanical (EM) models of the heart have been used successfully to study
fundamental mechanisms underlying a heart beat in health and disease. However, in all …

This study examines the effect of mental workload on the electrocardiogram (ECG) of
participants driving the Lane Change Task (LCT). Different levels of mental workload were …