Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia
BJP Huntly, A Bench, AR Green - Blood, 2003 - ashpublications.org
Chronic myeloid leukemia (CML) is characterized by formation of a BCR-ABL fusion gene,
usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 …
usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 …
Initial diagnosis of chronic myelogenous leukemia based on quantification of M-BCR status using droplet digital PCR
HL Lund, CB Hughesman, K McNeil, S Clemens… - Analytical and …, 2016 - Springer
Formed from a reciprocal translocation t (9: 22)(q34; q11) of genetic material between the
long arms of human chromosomes 9 and 22, the constitutively active breakpoint cluster …
long arms of human chromosomes 9 and 22, the constitutively active breakpoint cluster …
Clinical implications of der (9q) deletions detected through dual-fusion fluorescence in situ hybridization in patients with chronic myeloid leukemia
MGV de Campos, FT Montesano, MM Rodrigues… - Cancer genetics and …, 2007 - Elsevier
Poor outcomes of some chronic myeloid leukemia ((CML) patients have been associated
with submicroscopic der (9q) deletions, particularly the 5′ ABL region. Deletion profiles of …
with submicroscopic der (9q) deletions, particularly the 5′ ABL region. Deletion profiles of …
Deletion of any part of the BCR or ABL gene on the derivative chromosome 9 is a poor prognostic marker in chronic myelogenous leukemia
YK Lee, YR Kim, HC Min, BR Oh, TY Kim… - Cancer genetics and …, 2006 - Elsevier
To evaluate the prognostic significance of submicroscopic deletions of the ABL or BCR gene
associated with t (9; 22) in chronic myelogenous leukemia (CML), we investigated the …
associated with t (9; 22) in chronic myelogenous leukemia (CML), we investigated the …
Deletion of the 5'ABL region in Philadelphia chromosome positive chronic myeloid leukemia: frequency, origin and prognosis
F Morel, C Ka, MJ Le Bris, A Herry, P Morice… - Leukemia & …, 2003 - Taylor & Francis
The use of new nuclei probes in fluorescent in situ hybridization (FISH) at diagnosis and
during follow up has recently allowed the detection of a deletion of the 5′ abl region on the …
during follow up has recently allowed the detection of a deletion of the 5′ abl region on the …
Deletion of the 5′ abl region in Philadelphia chromosome-positive chronic myeloid leukemia
F Morel, C Ka, MJ Le Bris, A Herry, P Morice… - Leukemia, 2003 - nature.com
Chronic myeloid leukemia (CML) is a myeloproliferative disorder which originates in a
multipotent hematopoietic stem cell. 95% of the CML patients have a Philadelphia (Ph) …
multipotent hematopoietic stem cell. 95% of the CML patients have a Philadelphia (Ph) …
[PDF][PDF] The incidence of atypical patterns of BCR-ABL1 rearrangement and molecular-cytogenetic response to tyrosine kinase inhibitor therapy in newly diagnosed …
Background To analyze the frequency of atypical fluorescence in situ hybridization signal
patterns and estimate the complete cytogenetic response (CCyR) and major molecular …
patterns and estimate the complete cytogenetic response (CCyR) and major molecular …
Análise citogenética e FISH no monitoramento da LMC em tratamento com inibidores da tirosino quinase
MLLF Chauffaille - Revista Brasileira de Hematologia e Hemoterapia, 2008 - SciELO Brasil
O monitoramento de tratamento com inibidor da tirosinoquinase (TK) tem sido feito com os
objetivos de avaliar o sucesso da terapia e de definircondutas específicas nos casos nos …
objetivos de avaliar o sucesso da terapia e de definircondutas específicas nos casos nos …
Molecular cytogenetic study of derivative chromosome 9 deletion in chronic myeloid leukemia patients
A Bennour, I Ouahchi, Y Ben Youssef, M Zaier… - Medical Oncology, 2012 - Springer
The aims of this study are to investigate the frequency of derivative chromosome 9 (der (9))
deletion in Tunisian patients with chronic myeloid leukemia (CML) and to assess the …
deletion in Tunisian patients with chronic myeloid leukemia (CML) and to assess the …
Interpretation of submicroscopic deletions of the BCR or ABL gene should not depend on extra signal‐FISH: Problems in interpretation of submicroscopic deletion of the BCR …
YR Kim, HI Cho, SS Yoon, S Park… - Genes …, 2005 - Wiley Online Library
Several groups have demonstrated that a submicroscopic gene deletion in Ph+ chronic
myelogenous leukemia (CML) is associated with a poor prognosis and reduced response to …
myelogenous leukemia (CML) is associated with a poor prognosis and reduced response to …