Following antigen encounter and subsequent resolution of the immune response, a single
naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic …

Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …

BACKGROUND. T cells that have been modified to express a CD19-specific chimeric
antigen receptor (CAR) have antitumor activity in B cell malignancies; however, identification …

CD19-specific chimeric antigen receptor (CAR)–modified T cells have antitumor activity in B
cell malignancies, but factors that affect toxicity and efficacy have been difficult to define …

Central memory T (TCM) cells patrol lymph nodes and perform conventional memory
responses on restimulation: proliferation, migration and differentiation into diverse T cell …

Immunological memory is thought to depend on a stem cell–like, self-renewing population of
lymphocytes capable of differentiating into effector cells in response to antigen re-exposure …

CD8+ T cell immunosurveillance dynamics influence the outcome of intracellular infections
and cancer. Here we used two-photon intravital microscopy to visualize the responses of …

Long-living memory stem T cells (TSCM) with the ability to self-renew and the plasticity to
differentiate into potent effectors could be valuable weapons in adoptive T-cell therapy …

Th17 cells have been described as short lived, but this view is at odds with their capacity to
trigger protracted damage to normal and transformed tissues. We report that Th17 cells …

Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the
treatment of cancer and certain chronic viral infections. The application of the principles of …