Dexmedetomidine (DEX), a highly specific α2‑adrenergic agonist, which exhibits
anaesthetic‑sparing, analgesia and sympatholytic properties. DEX modulates gene …

Intestinal ischemic reperfusion injury (IIRI) is a life-threatening condition with high morbidity
and mortality in the clinic. IIRI was induced by intestinal ischemic diseases such as, small …

Background The α 2-adrenoreceptor agonist dexmedetomidine is known to provide
renoprotection against ischemia and reperfusion (I/R) injury. However the underlying …

Background Intestinal ischemia/reperfusion (I/R) is a common clinical problem that occurs
during various clinical pathological processes. Dexmedetomidine (DEX), a widely used …

Kidney ischemia‐reperfusion (I/R) injury is a common cause of acute kidney injury. We
tested whether dexmedetomidine (Dex), an alpha2 adrenoceptor (α2‐AR) agonist, protects …

Objective. With the increasing incidence of diabetes mellitus (DM) combined with myocardial
ischemia, how to reduce myocardial ischemia‐reperfusion injury in DM patients has become …

Dexmedetomidine (DEX) is a highly selective and potent α2-adrenoceptor (α2-AR) agonist
that is widely used as a clinical anesthetic to induce anxiolytic, sedative, and analgesic …

Intestinal ischemia/reperfusion (I/R), which is associated with high morbidity and mortality, is
also accompanied with abnormal energy metabolism and liver injury. Irisin, a novel exercise …

Dexmedetomidine (DEX) affords a hepatoprotective effect during ischemia–reperfusion (IR)
injury (IRI); however, the underlying mechanism remains elusive. In this work, using a rat …

Cardiopulmonary bypass (CPB) is associated with a marked systemic inflammatory
response. Although dexmedetomidine (Dex) is routinely used in cardiac surgery, the effect in …