Factors and interventions affecting tacrolimus intrapatient variability: A systematic review and meta-analysis
H Chen, S Liu, L Yu, X Hou, R Zhao - Transplantation Reviews, 2024 - Elsevier
Background Tacrolimus is a cornerstone of posttransplantation immunosuppressive
regimens. Despite routine monitoring, the efficacy of its trough concentrations in reflecting …
regimens. Despite routine monitoring, the efficacy of its trough concentrations in reflecting …
Tacrolimus—why pharmacokinetics matter in the clinic
L Henkel, U Jehn, G Thölking, S Reuter - Frontiers in Transplantation, 2023 - frontiersin.org
The calcineurin inhibitor (CNI) Tacrolimus (Tac) is the most prescribed immunosuppressant
drug after solid organ transplantation. After renal transplantation (RTx) approximately 95% of …
drug after solid organ transplantation. After renal transplantation (RTx) approximately 95% of …
[HTML][HTML] Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation
MC Morais, ME Soares, G Costa, L Guerra… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Tacrolimus (Tac) is currently the most common calcineurin-inhibitor employed in solid organ
transplantation. High intra-patient variability (IPV) of Tac (Tac IPV) has been associated with …
transplantation. High intra-patient variability (IPV) of Tac (Tac IPV) has been associated with …
Impact of IL-6 and IL-10 genotypes on tacrolimus dose requirements in kidney transplant recipients: Monte Carlo analysis
N Stefanović, K Danković, T Cvetković, S Vujić… - …, 2024 - Taylor & Francis
Introduction: IL-6 and IL-10 may affect the activity of cytochrome P450 (CYP) 3A enzymes
involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac …
involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac …
Can Pre-Transplant Psychometric Testing Predict Tacrolimus Intrapatient Variability After Living Kidney Transplantation?
AR Lee, SM Lee, WS Kang, AR Cho… - Psychiatry …, 2024 - pmc.ncbi.nlm.nih.gov
Objective Tacrolimus intrapatient variability (Tac IPV) has been considered a marker for post-
graft risk. We investigated pre-transplant psychometric testing to predict Tac IPV after living …
graft risk. We investigated pre-transplant psychometric testing to predict Tac IPV after living …
Potential influence of interleukin-6-174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up
K Danković, N Stefanović, T Cvetković, S Vujić… - Xenobiotica, 2024 - Taylor & Francis
Introduction The study aimed to investigate the influence of interleukin (IL)-6-174 G/C gene
polymorphism on graft function (defined as estimated glomerular filtration rate, eGFR), as …
polymorphism on graft function (defined as estimated glomerular filtration rate, eGFR), as …
Pharmacogenomics and Precision Therapy in Prostate Cancer: Challenges and Perspectives
N Stefanović - Prostate Cancer: Advancements in the Pathogenesis …, 2024 - Springer
Advancements in genotyping and sequencing technologies have driven the rapid progress
in human genetics research over the last 20 years. Particularly noteworthy is the emergence …
in human genetics research over the last 20 years. Particularly noteworthy is the emergence …
Significance of determination of tacrolimus intraindividual variability and pharmacogenetic markers in kidney transplant recipients
N Stefanović - Archives of Pharmacy, 2022 - aseestant.ceon.rs
In the last three decades, a significant success was achieved in short-term outcomes after
kidney transplantation, but it has not been followed with the same progress in long-term post …
kidney transplantation, but it has not been followed with the same progress in long-term post …