The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various
immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to …

Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …

In the past decade, increasing efforts have been devoted to the study of galectins, a family of
evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins …

Galectins are an evolutionarily ancient family of glycan-binding proteins (GBPs) and are
found in all animals. Although they were discovered over 30 years ago, ideas about their …

The recent understanding of plasma cell (PC) biology has been obtained mainly from
murine models. The current concept is that plasmablasts home to the BM and further …

Plasma cells (PCs), the terminal effectors of humoral immunity, are short-lived unless
supported by niche environments in which they may persist for years. No model system has …

Abstract Galectin-1 (Gal-1), a carbohydrate-binding protein whose secretion is enhanced by
hypoxia, promotes tumor aggressiveness by promoting angiogenesis and T-cell apoptosis …

Galectins are animal lectins that bind to β‐galactosides, such as lactose and N‐
acetyllactosamine, in free form or contained in glycoproteins or glycolipids. They are located …

To understand the biological functions of lectins, it is important to investigate their sugar-
binding specificity. Although galectins are characterized as β-galactoside-binding proteins …