Every sixth person in the world dies due to cancer, making it the second leading severe
cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 …

A brain organoid is a self-organizing three-dimensional tissue derived from human
embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and …

The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of
approximately 15 months. Current preclinical GBM models are limited by the lack of a" …

In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

In this chapter we have presented mathematical modeling approaches to biological pattern
formation. While reaction-diffusion models are appropriate to describe the spatio-temporal …

Cancer is a complex, multiscale process in which genetic mutations occurring at a
subcellular level manifest themselves as functional changes at the cellular and tissue scale …

Despite a growing wealth of available molecular data, the growth of tumors, invasion of
tumors into healthy tissue, and response of tumors to therapies are still poorly understood …

We present a 3D multi-cell simulation of a generic simplification of vascular tumor growth
which can be easily extended and adapted to describe more specific vascular tumor types …

Gelation temperatures from 22° C to 37° C were used to control the pore size of collagen
matrices independent of collagen concentration. To limit cell exposure to temperatures lower …