Background The interest in mechanics of synthetic and biological vesicles has been
continuously growing during the last decades. Liposomes serve as model systems for …

The rigidity of nanoliposomes significantly influences their physical stability and in vitro and
in vivo behaviors (eg, cellular uptake, blood circulation, biodistribution, etc.). This study …

Mechanical rigidity of the liposome membrane is often defined by the membrane bending
modulus and is one of the determinants of liposome stability, but the quantitative …

Delivery of messenger RNA (mRNA) using lipid nanoparticles (LNPs) is expected to be
applied to various diseases following the successful clinical use of the mRNA COVID-19 …

The efficacy of mRNA-lipid nanoparticles (mRNA-LNPs) depends on several factors,
including their size and morphology. This study presents a new technique to characterize …

Effective penetration of drug-carrying nanoparticles into solid tumors is a major challenge in
cancer therapy. Exploration of the physicochemical properties of nanoparticles that affect …

It has recently been recognized that the mechanical properties of lipid nanoparticles play an
important role during in vitro and in vivo behaviors such as cellular uptake, blood circulation …

We determined the permeability coefficient of a model hydrophilic drug, calcein,
encapsulated within saturated lipid-based nano-sized liposomes of various lipid profiles. We …

The stiffness of nanoscale liposomes, as measured by atomic force microscopy (AFM), was
investigated as a function of temperature, immobilization on solid substrates, and cantilever …

Liposomes are a widely used as drug loaded carriers in different drug administration routes.
Membrane fluidity is a fundamental physicochemical property of liposomes which describes …