Epigenetics across the evolutionary tree: New paradigms from non‐model animals

KC Sadler - BioEssays, 2023 - Wiley Online Library
All animals have evolved solutions to manage their genomes, enabling the efficient
organization of meters of DNA strands in the nucleus and allowing for nuanced regulation of …

Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis

CT Rhodes, CHA Lin - Neural Regeneration Research, 2023 - journals.lww.com
Mechanisms regulating neurogenesis involve broad and complex processes that represent
intriguing therapeutic targets in the field of regenerative medicine. One influential factor …

Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice

Y Chen, L Chen, X Wu, Y Zhao, Y Wang… - Nature …, 2023 - nature.com
The early phase lipid accumulation is essential for liver regeneration. However, whether this
acute lipid accumulation can serve as signals to direct liver regeneration rather than simply …

Hepatocyte regeneration is driven by embryo-like DNA methylation reprogramming

T Falick Michaeli, O Sabag, B Azria… - Proceedings of the …, 2024 - National Acad Sciences
As a result of partial hepatectomy, the remaining liver tissue undergoes a process of
renewed proliferation that leads to rapid regeneration of the liver. By following the early …

MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration

J Du, W Liao, H Wang, G Hou, M Liao, L Xu… - … and Targeted Therapy, 2023 - nature.com
The mineral dust-induced gene (MDIG) comprises a conserved JmjC domain and has the
ability to demethylate histone H3 lysine 9 trimethylation (H3K9me3). Previous studies have …

Lineage Plasticity and Stemness Phenotypes in Prostate Cancer: Harnessing the Power of Integrated “Omics” Approaches to Explore Measurable Metrics

S Logotheti, E Papadaki, V Zolota, C Logothetis… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer remains the most frequent cause of cancer morbidity, the
second most frequent cause of cancer mortality in men in the developed world and is an …

Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration

B Wang, H Shen, Y Wei, F Liu, Y Yang, H Yu, J Fu… - Journal of …, 2024 - Elsevier
Background & Aims Post-hepatectomy liver failure (PHLF) leads to poor prognosis in
patients undergoing hepatectomy, with hepatic vascular reconstitution playing a critical role …

Transposon control as a checkpoint for tissue regeneration

KM Angileri, NA Bagia, C Feschotte - Development, 2022 - journals.biologists.com
Tissue regeneration requires precise temporal control of cellular processes such as
inflammatory signaling, chromatin remodeling and proliferation. The combination of these …

Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration

B Wang, H Shen, Y Wei, F Liu, Y Yang, H Yu… - J …, 2023 - journal-of-hepatology.eu
Background & Aims: Post-hepatectomy liver failure (PHLF) leads to poor prognosis in
patients undergoing hepatectomy, with hepatic vascular reconstitution playing a critical role …

The Hypothalamic Epigenetic Landscape in Dietary Obesity

K Ma, K Yin, J Li, L Ma, Q Zhou, X Lu, B Li… - Advanced …, 2024 - Wiley Online Library
The hypothalamus in the brain plays a pivotal role in controlling energy balance in
vertebrates. Nutritional excess through high‐fat diet (HFD) feeding can dysregulate …