New progresses on cell surface protein HSPA5/BiP/GRP78 in cancers and COVID-19
T Li, J Fu, J Cheng, AA Elfiky, C Wei, J Fu - Frontiers in Immunology, 2023 - frontiersin.org
Heat-shock-protein family A (Hsp70) member 5 (HSPA5), aliases GRP78 or BiP, is a protein
encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33. 3 …
encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33. 3 …
GRP78 inhibitor YUM70 suppresses SARS-CoV-2 viral entry, spike protein production and ameliorates lung damage
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
the COVID-19 pandemic, has given rise to many new variants with increased transmissibility …
the COVID-19 pandemic, has given rise to many new variants with increased transmissibility …
[HTML][HTML] Host-cell recognition of SARS-CoV-2 spike receptor binding domain from different variants
A recent letter in this journal described an avian influenza virus of wild bird origin that is well
adapted to a mammalian host, posing a potential threat to animal and human health. 1 This …
adapted to a mammalian host, posing a potential threat to animal and human health. 1 This …
Roles of TGF-β1 in Viral Infection during Pregnancy: Research Update and Perspectives
Transforming growth factor-beta 1 (TGF-β1) is a pleiotropic growth factor playing various
roles in the human body including cell growth and development. More functions of TGF-β1 …
roles in the human body including cell growth and development. More functions of TGF-β1 …
Cs-GRP78 Recognition Site on Dengue Virus Envelope Protein: in silico perspective
AA Elfiky, A Amr, A Mosaad, AK Mubarak… - Future …, 2023 - Taylor & Francis
Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell
factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV …
factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV …
[HTML][HTML] Sequence analysis of hot spot regions of spike and RNA-dependent-RNA polymerase (RdRp) genes of SARS-CoV-2 in Kerman, Iran
Background Mutations in the SARS-CoV-2 genome might influence pathogenicity,
transmission rate, and evasion of the host immune system. Therefore, the purpose of the …
transmission rate, and evasion of the host immune system. Therefore, the purpose of the …
Direct interaction of the molecular chaperone GRP78/BiP with the Newcastle disease virus hemagglutinin-neuraminidase protein plays a vital role in viral attachment …
C Han, Z Xie, Y Lv, D Liu, R Chen - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Glucose Regulated Proteins/Binding protein (GRP78/Bip), a representative
molecular chaperone, effectively influences and actively participates in the replication …
molecular chaperone, effectively influences and actively participates in the replication …
SARS‐CoV‐2 Spike Protein‐Derived Cyclic Peptides as Modulators of Spike Interaction with GRP78
N Johnson, C Pattinson, K Burgoyne, K Hijazi… - …, 2024 - Wiley Online Library
The human glucose‐regulated protein GRP78 is a human chaperone that translocactes to
the cell surface when cells are under stress. Theoretical studies suggested it could be …
the cell surface when cells are under stress. Theoretical studies suggested it could be …
Molecular interaction analysis of anti-IL-8 scFv-10F8-6His against IL-8 monomer through molecular docking and molecular dynamic simulations
FFN Abdul Kadir, MA Che Nordin… - Journal of …, 2023 - Taylor & Francis
Abstract Elevated interleukin 8 (IL-8) expression has been linked to unfavorable outcomes in
a range of inflammatory conditions, such as rheumatoid arthritis, psoriasis, and cancer. The …
a range of inflammatory conditions, such as rheumatoid arthritis, psoriasis, and cancer. The …
The emergence of a novel SARS-CoV-2 variant with higher efficiency of binding with the human host cell receptors in Iraqi subjects
The objective of this study was to assess the impact of variations in the surface glycoprotein
of SARS-CoV-2, which is generated by the spike (S) gene, on its interaction with host …
of SARS-CoV-2, which is generated by the spike (S) gene, on its interaction with host …