Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

Cancer is a complex illness that presents significant challenges in its understanding and
treatment. The classic definition," a group of diseases characterized by the uncontrolled …

Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

Breast cancer is very heterogeneous and the most frequently diagnosed cancer worldwide,
and precise therapy targeting specific subtypes may improve the survival rates of breast …

Pyroptosis is an inflammatory form of programmed cell death that holds great promise in
cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self …

The regulation of intracellular ions' overload to interrupt normal bioprocesses and cause cell
death has been developed as an efficient strategy (named as ion-interference therapy/IIT) to …

As a burgeoning bioorthogonal reaction, the fluoride-mediated desilylation is capable of
prodrug activation. However, due to the reactions lack of cell selectivity and unitary therapy …

It is known that extracellular free radical reactive oxygen species (ROS) rather than
intracellular ROS plays a non‐substitutable role in regulation of tumor‐suppressing (M1) …

Nanozymes have been designed to address the limitations of high cost and poor stability
involving natural enzymes in analytical applications. However, the catalytic efficiency of the …

Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has been widely regarded as
a promising avenue in bioorthogonal chemistry. The emerging heterogeneous copper …