Vascular endothelial growth factors (VEGFs) are the key regulators of vasculogenesis in
normal and oncological development. VEGF-A is the most studied angiogenic factor …

In recent years, the study of lymphangiogenesis and fibrotic diseases has made
considerable achievements, and accumulating evidence indicates that lymphangiogenesis …

Vascular endothelial growth factor receptor-3 (VEGFR-3) is known to participate in
tumorigenesis and lymphangiogenesis, and as such, has the potential to serve as a …

Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important
steps in cancer metastasis, and are associated with patient's poor prognosis. There is …

Tumor-induced lymphangiogenesis is strongly associated with the formation of tumor
metastasis. Therefore, the regulation of lymphangiogenesis offers a promising target in …

Silicosis is a disease characterized by lung inflammation and fibrosis caused by long-term
inhalation of free silicon dioxide (SiO 2). Recent studies have found that a large number of …

Objectives Lymphatic metastasis, an early stage of the metastasis process, is associated
with adverse clinical outcomes in urothelial carcinoma of the bladder (UCB). However, the …

Accumulating evidence suggests that lymphangiogenesis plays a crucial role in lymphatic
metastasis, leading to tumor immune tolerance. However, the specific mechanism remains …

Rituximab, an anti-CD20 monoclonal antibody, has revolutionized the treatment for
lymphoma, particularly B-cell non-Hodgkin lymphoma; the therapeutic efficacy, however, is …