Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices–A mini review

RV Badhe, O Akinfosile, D Bijukumar, M Barba… - Toxicology letters, 2021 - Elsevier
The metal/metal alloy-based implants and prostheses are in use for over a century, and the
rejections, revisions, and metal particle-based toxicities were reported concurrently …

Understanding the role of inflammation in sensorineural hearing loss: current goals and future prospects

L Li, D Chen, X Lin, J Luo, J Tan, P Li - Brain‐X, 2023 - Wiley Online Library
Sensorineural hearing loss (SNHL) is a common otologic condition caused by damage to
hair cells and spiral ganglion neurons that affects transmission pathways. Most of these cells …

Cobalt exposure and dyslipidemia in elderly population: the mediating role of systemic inflammation and lipid peroxidation

JH Huang, L Tao, Y Wu, W He, JX Wang… - … Science and Pollution …, 2023 - Springer
Heavy metal exposure has been reported to be correlated with lipid profile alteration and
dyslipidemia. While the associations between serum cobalt (Co) with lipid profile levels and …

[HTML][HTML] Association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes in a US population: a cross-sectional study

H Wang, F Li, J Xue, Y Li, J Li - Medicine, 2022 - journals.lww.com
Various heavy metal elements in the human body have been reported to be associated with
dyslipidemia, hypertension, and diabetes. The role of cobalt in these conditions is unclear …

The association of cobalturia with cobaltism symptoms a prospective blinded study of 229 post-arthroplasty patients

SS Tower, BD Gessner, CS Cho, RL Bridges - Plos one, 2023 - journals.plos.org
Introduction Cobalt is a mitochondrial toxin, clinical cobaltism manifests with constitutional,
neurologic, and cardiovascular symptomatology. Cobalt's severe toxidrome is known …

[HTML][HTML] Cobalt-induced apoptosis of cochlear organotypic cultures and HEI-OC1 cells is mediated by Dicer

X Lin, L Li, J Luo, D Chen, J Tan, P Li - NeuroToxicology, 2024 - Elsevier
Cobalt is widely used in the medical industry, mainly including cobalt alloy joint implants and
cobalt-chromium porcelain crowns. However, unexplained ototoxicity and neurotoxicity often …

[HTML][HTML] Local and systemic consequences of metal-on-metal hip resurfacing implants

P Campbell, K Takamura - Annals of Joint, 2020 - aoj.amegroups.org
Hip resurfacing arthroplasty (HRA) has a long clinical history and has utilized a variety of
bearing material combinations with mixed clinical success. This paper reviews the local and …

Phenotyping vestibulocochlear manifestations in Susac syndrome: a cohort study

A Roelens, M Vandekerckhove, L Maes… - European Archives of …, 2024 - Springer
Purpose To characterize vestibulocochlear involvement in patients with Susac syndrome
(SuS), a rare immune-mediated endotheliopathy of cerebral, retinal and inner ear …

[HTML][HTML] Significantly less wear of UHMWPE rubbing against pyrocarbon than against CoCr

TJ Joyce, G Ouenzerfi, G Kandemir, I Trail… - Journal of the …, 2024 - Elsevier
The history of joint replacement can be framed as a battle to reduce wear. Pyrocarbon has
been shown to be a low wear material, but can low wear against an ultra high molecular …

[PDF][PDF] Otologic Symptoms in 2 Patients with Cobalt-Containing Hip Prostheses

M Caballero-Borrego, M Turner, F Larrosa - B-ENT, 2024 - b-ent.be
Systemic poisoning related to cobalt–chromium total hip arthroplasty can affect multiple
organs. In the otolaryngologic area the most frequent symptoms are tinnitus and hearing …