The significance of mitochondrial dysfunction in cancer
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
Lactate in the tumor microenvironment: an essential molecule in cancer progression and treatment
R Pérez-Tomás, I Pérez-Guillén - Cancers, 2020 - mdpi.com
Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …
cancer cells uptake high amount of glucose with a marked increase in lactate production …
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
K Hu, K Li, J Lv, J Feng, J Chen, H Wu… - The Journal of …, 2020 - Am Soc Clin Investig
Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be
therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays …
therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays …
VISTA: a mediator of quiescence and a promising target in cancer immunotherapy
V-domain Ig suppressor of T cell activation (VISTA) is a B7 family member that maintains T
cell and myeloid quiescence and is a promising target for combination cancer …
cell and myeloid quiescence and is a promising target for combination cancer …
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
SS Sabharwal, PT Schumacker - Nature Reviews Cancer, 2014 - nature.com
Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …
[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy
Y Yang, S Karakhanova, W Hartwig… - Journal of cellular …, 2016 - Wiley Online Library
Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …
MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis
R Deng, HL Zhang, JH Huang, RZ Cai, Y Wang… - Autophagy, 2021 - Taylor & Francis
The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …
macroautophagy/autophagy and has a more specific role in mitophagy in response to …
Tumor glycolysis as a target for cancer therapy: progress and prospects
S Ganapathy-Kanniappan, JFH Geschwind - Molecular cancer, 2013 - Springer
Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of
the “hallmarks of cancer”. This metabolic phenotype is characterized by preferential …
the “hallmarks of cancer”. This metabolic phenotype is characterized by preferential …
Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy
S Wang, JL Fu, HF Hao, YN Jiao, PP Li… - Pharmacological …, 2021 - Elsevier
Metabolic reprogramming, characterized by alterations of cellular metabolic patterns, is
fundamentally important in supporting the malignant behaviors of cancer cells. It is …
fundamentally important in supporting the malignant behaviors of cancer cells. It is …