As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be
therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays …

V-domain Ig suppressor of T cell activation (VISTA) is a B7 family member that maintains T
cell and myeloid quiescence and is a promising target for combination cancer …

Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …

Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of
the “hallmarks of cancer”. This metabolic phenotype is characterized by preferential …

Metabolic reprogramming, characterized by alterations of cellular metabolic patterns, is
fundamentally important in supporting the malignant behaviors of cancer cells. It is …