Introduction With a worldwide ageing population, the importance of the prevention and
management of osteoporotic fragility fractures is increasing over time. In this review, we …

This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

Background Birth weight, a marker of the intrauterine environment, has been extensively
studied in epidemiological research in relation to subsequent health and disease. Although …

Osteoporosis is an ageing disorder characterised by poor microstructural architecture of the
bone and an increase in the risk of fragility fractures, which often leads to hospitalisation and …

This narrative review discusses several aspects of the management of osteoporosis in
patients under 50 years of age. Peak bone mass is genetically determined but can also be …

Non-communicable diseases (NCDs) including obesity, diabetes and cardiovascular
disease, musculoskeletal, mental and neurological disorders have been identified as the …

A cross-sectional survey was conducted in Shanghai, eastern China, to evaluate the
prevalence of loss of muscle mass corresponding to sarcopenia in Chinese men and …

It is uncertain whether the vitamin D status of pregnant women influences bone mass of their
children. Cohort studies have yielded conflicting results; none have examined offspring at …

Sarcopenia is associated with a greater fracture risk. This relationship was originally thought
to be explained by an increased risk of falls in sarcopenic individuals. However, in addition …

It is becoming increasingly apparent that the risk of developing osteoporosis is accrued
throughout the entire lifecourse, even from as early as conception. Thus early growth is …