Shining light on polymeric drug nanocarriers with fluorescence correlation spectroscopy
The use of nanoparticles as carriers is an extremely promising way for administration of
therapeutic agents, such as drug molecules, proteins, and nucleic acids. Such nanocarriers …
therapeutic agents, such as drug molecules, proteins, and nucleic acids. Such nanocarriers …
Fluorescence correlation spectroscopy as a tool for the study of the intracellular dynamics and biological fate of protein corona
M Martinez-Moro, D Di Silvio, SE Moya - Biophysical Chemistry, 2019 - Elsevier
In biological fluids, nanoparticles (NPs) are in contact with proteins and other biomolecules.
Proteins adsorb to NPs and form a coating called a protein corona (PC). The PC is known to …
Proteins adsorb to NPs and form a coating called a protein corona (PC). The PC is known to …
The mechanism of dynamic interaction between doxorubicin and calf thymus DNA at the single-molecule level based on confocal Raman spectroscopy
R Zhang, J Zhu, D Sun, J Li, L Yao, S Meng, Y Li… - Micromachines, 2022 - mdpi.com
It is of great fundamental significance and practical application to understand the binding
sites and dynamic process of the interaction between doxorubicin (DOX) and DNA …
sites and dynamic process of the interaction between doxorubicin (DOX) and DNA …
Thermodynamic dissection of the intercalation binding process of doxorubicin to dsDNA with implications of ionic and solvent effects
B Jawad, L Poudel, R Podgornik… - The Journal of Physical …, 2020 - ACS Publications
Doxorubicin (DOX) is a cancer drug that binds to dsDNA through intercalation. A
comprehensive microsecond timescale molecular dynamics study is performed for DOX with …
comprehensive microsecond timescale molecular dynamics study is performed for DOX with …
An ultrasensitive and preprocessing-free electrochemical platform for the detection of doxorubicin based on tryptophan/polyethylene glycol-cobalt ferrite nanoparticles …
Doxorubicin (DOX) is an anticancer drug which can effectively inhibit the growth of cancer
cells and aids the immune-mediated elimination of tumoral cells. Developing a new …
cells and aids the immune-mediated elimination of tumoral cells. Developing a new …
Preferential binding of epirubicin hydrochloride with single nucleotide mismatched DNA and subsequent sequestration by a mixed micelle
Targeting mismatched base pairs containing DNA using small molecules and exploring the
underlying mechanism involved during the binding interactions is one of the fundamental …
underlying mechanism involved during the binding interactions is one of the fundamental …
Uv-resonance Raman spectra of systems in complex environments: A multiscale modeling applied to doxorubicin intercalated into dna
UV-Resonance Raman (RR) spectroscopy is a valuable tool to study the binding of drugs to
biomolecular receptors. The extraction of information at the molecular level from …
biomolecular receptors. The extraction of information at the molecular level from …
Thermal reversibility and structural stability in lysozyme induced by epirubicin hydrochloride
Herein we report the binding interactions between lysozyme (Lyz) and an anthracycline
drug, epirubicin hydrochloride (EPR), through an extensive spectroscopic approach at both …
drug, epirubicin hydrochloride (EPR), through an extensive spectroscopic approach at both …
Discriminating single base pair mismatches in DNA using glutathione-templated copper nanoclusters
A single nucleotide mismatch in a particular sequence of DNA is considered to play pivotal
roles in various central biological processes and is associated with the development of …
roles in various central biological processes and is associated with the development of …
Assessing the Suitability of a Dicationic Ionic Liquid as a Stabilizing Material for the Storage of DNA in Aqueous Medium
The present study has been undertaken with an objective to find out a suitable medium for
the long-term stability and storage of the ct-DNA structure in aqueous solution. For this …
the long-term stability and storage of the ct-DNA structure in aqueous solution. For this …