Unlocking the potential of HK2 in cancer metabolism and therapeutics
SN Garcia, RC Guedes… - Current medicinal …, 2019 - ingentaconnect.com
Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …
Compound-based Chinese medicine formula: From discovery to compatibility mechanism
X Luan, LJ Zhang, XQ Li, K Rahman, H Zhang… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Chinese medicine formula (CMF) has a long history of
clinical use in the treatment of various diseases under the guidance of traditional Chinese …
clinical use in the treatment of various diseases under the guidance of traditional Chinese …
Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects
YL Wu, F Han, SS Luan, R Ai, P Zhang… - Journal of agricultural …, 2019 - ACS Publications
Ganoderma lucidum, as food, tea, dietary supplement, and medicine, is widely used in
China and Eastern Asian countries. In order to discover its anti-inflammatory constituents …
China and Eastern Asian countries. In order to discover its anti-inflammatory constituents …
Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight
Cancer has been progressively a major global health concern. With this developing global
concern, cancer determent is one of the most significant public health challenges of this era …
concern, cancer determent is one of the most significant public health challenges of this era …
Recent progress in research on the pharmacological potential of mushrooms and prospects for their clinical application
SM Badalyan, A Barkhudaryan, S Rapior - Medicinal mushrooms: recent …, 2019 - Springer
Fungi are considered one of the most diverse, ecologically significant, and economically
important organisms on Earth. The edible and medicinal mushrooms have long been known …
important organisms on Earth. The edible and medicinal mushrooms have long been known …
The development of small-molecule inhibitors targeting hexokinase 2
As one of the well-known hallmarks of cancer malignancy, most proliferating cancer cells
exhibit enhanced rates of glycolysis. Hexokinase 2 (HK2) is the rate-limiting enzyme …
exhibit enhanced rates of glycolysis. Hexokinase 2 (HK2) is the rate-limiting enzyme …
Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors
X Sun, Y Peng, J Zhao, Z Xie, X Lei, G Tang - Bioorganic Chemistry, 2021 - Elsevier
Tumor cells mainly provide necessary energy and substances for rapid cell growth through
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …
Studying molecular interactions via capillary electrophoresis and microscale thermophoresis: A review
M Asmari, L Michalcová, AE Ibrahim, Z Glatz… - …, 2023 - Wiley Online Library
The process of choosing the most proper technique for studying the molecular interactions is
based on critical factors such as instrumentation complexity, automation, experimental …
based on critical factors such as instrumentation complexity, automation, experimental …
[HTML][HTML] Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy
Mitochondria play a crucial part in the cell's ability to adapt to the changing
microenvironments and their dysfunction is associated with an extensive array of illnesses …
microenvironments and their dysfunction is associated with an extensive array of illnesses …
The role of reprogrammed glucose metabolism in cancer
MK Ediriweera, S Jayasena - Metabolites, 2023 - mdpi.com
Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various
microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by …
microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by …