Summary Background and Objective: Antibodies to human neutrophil antigens (HNAs) have
been implicated in transfusion-related acute lung injury and allo-and autoimmune …

Neutrophil extracellular traps (NETs) are involved in bacterial killing as well as
autoimmunity, because NETs contain proteases, bactericidal peptides, DNA and …

ABSTRACT OLFM4 was identified initially as a gene highly induced in myeloid stem cells by
G-CSF treatment. A bioinformatics method using a global meta-analysis of microarray data …

Granulocytes are an essential part of both the innate and adaptive immune systems. Human
neutrophil antigens (HNAs) are a family of epitopes that are located on glycoproteins that …

Objective Differential gene expression in CD177+ and CD177− neutrophils was
investigated, in order to detect possible differences in neutrophil function which could be …

Most humans harbor both CD177neg and CD177pos neutrophils but 1–10% of people are
CD177null, placing them at risk for formation of anti-neutrophil antibodies that can cause …

Human neutrophil antigen 2 (HNA-2) deficiency is a common phenotype as 3–5% humans
do not express HNA-2. HNA-2 is coded by CD177 gene that associates with human …

CD177 presents antigens in allo-and autoimmune diseases on the neutrophil surface.
Individuals can be either CD177-deficient or harbor distinct CD177neg and CD177pos …

Neonatal alloimmune neutropenia (NAIN, NAIN or NIN) is a neutrophil blood group
antagonism, analogous to hemolytic disease of the fetus and newborn (HDFN) and …

Characterization of the HNA-3 system allows identification of blood donors at risk to develop
HNA-3-antibodies. FcγRIIIb (HNA-1) and CD177 (HNA-2) seem to be important in bacterial …