The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Abstract One-carbon (C1) substrates are preferred feedstocks for the biomanufacturing
industry and have recently gained attention owing to their natural abundance, low …

Starches, a storage form of carbohydrates, are a major source of calories in the human diet
and a primary feedstock for bioindustry. We report a chemical-biochemical hybrid pathway …

Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

Highlights•One-carbon compounds can be made from CO 2 to provide renewable microbial
feedstocks.•Methanol and formate have key advantages over gaseous one-carbon …

Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

CO2 sequestration engineering is an attractive strategy for achieving carbon-and energy-
efficient bioproduction. However, the efficiency of heterotrophic CO2 sequestration is limited …

Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

BACKGROUND Environmental, geopolitical, and economic factors are reshaping our view
of global energy and manufacturing demands. Addressing these challenges may require a …

Methanol, an organic one-carbon (C1) compound, represents an attractive alternative
carbon source for microbial fermentation. Despite considerable advancements in methanol …