Biocatalysis: enzymatic synthesis for industrial applications

S Wu, R Snajdrova, JC Moore… - Angewandte Chemie …, 2021 - Wiley Online Library
Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Religious‐based negative attitudes towards LGBTQ people among healthcare, social care and social work students and professionals: A review of the international …

S Westwood - Health & Social Care in the Community, 2022 - Wiley Online Library
There is a dearth of research on how negative religious attitudes towards LGBTQ people
inform professional practice. This paper reports on a scoping review of 70 selected studies …

A growth selection system for the directed evolution of amine-forming or converting enzymes

S Wu, C Xiang, Y Zhou, MSH Khan, W Liu… - Nature …, 2022 - nature.com
Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …

Oxidoreductase-catalyzed synthesis of chiral amines

MD Patil, G Grogan, A Bommarius, H Yun - Acs Catalysis, 2018 - ACS Publications
Chiral amines are valuable constituents of many important pharmaceutical compounds and
their intermediates. It is estimated that∼ 40%–45% of small molecule pharmaceuticals …

Reductive aminations by imine reductases: from milligrams to tons

AK Gilio, TW Thorpe, N Turner, G Grogan - Chemical Science, 2022 - pubs.rsc.org
The synthesis of secondary and tertiary amines through the reductive amination of carbonyl
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …

Advances in one-pot chiral amine synthesis enabled by amine transaminase cascades: pushing the boundaries of complexity

S Mathew, D Renn, M Rueping - ACS Catalysis, 2023 - ACS Publications
Amine transaminases constitute an important class of enzymes for the synthesis of chiral
amines, which are commonly used as building blocks in pharmaceutical compounds and …

Biocatalysis as useful tool in asymmetric synthesis: An assessment of recently granted patents (2014–2019)

PD de María, G de Gonzalo, AR Alcántara - Catalysts, 2019 - mdpi.com
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical
fields are interconnected and synergized. A way to depict that innovation is by conducting a …

Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

S Wu, R Snajdrova, JC Moore, K Baldenius… - Angewandte …, 2021 - Wiley Online Library
Die Biokatalyse hat in verschiedenen Einsatzgebieten Anwendung als Alternative zur
chemischen Katalyse gefunden, wobei die herausragendsten Beispiele die Herstellung …

Transaminases for industrial biocatalysis: novel enzyme discovery

SA Kelly, S Mix, TS Moody, BF Gilmore - Applied microbiology and …, 2020 - Springer
Transaminases (TAms) are important enzymes for the production of chiral amines for the
pharmaceutical and fine chemical industries. Novel TAms for use in these industries have …

One-pot biocatalytic transformation of adipic acid to 6-aminocaproic acid and 1, 6-hexamethylenediamine using carboxylic acid reductases and transaminases

TP Fedorchuk, AN Khusnutdinova… - Journal of the …, 2019 - ACS Publications
Production of platform chemicals from renewable feedstocks is becoming increasingly
important due to concerns on environmental contamination, climate change, and depletion …