There is considerable interest in mining organisms for new natural products (NPs) and in
improving methods to overproduce valuable NPs. Because of the rapid development of tools …

Soil dwelling Streptomyces species are faced with large variations in carbon or nitrogen
sources, phosphate, oxygen, iron, sulfur, and other nutrients. These drastic changes in key …

Fengycin is a cyclic lipopeptide complex produced by Bacillus species. The focus of this
study was to improve fengycin titer through promoter replacement and fatty acid pathway …

Natural products (NPs) and their derivatives are widely used as frontline treatments for many
diseases. Actinobacteria spp. are used to produce most of NP antibiotics and have also …

The anticoccidial salinomycin is a polyketide produced by Streptomyces albus and requires
malonyl-CoAs, methylmalonyl-CoAs, and ethylmalonyl-CoAs for the backbone assembly …

Primary metabolism plays a key role in the synthesis of secondary metabolite. In this study,
the main transcription factors in carbon, nitrogen, and phosphorus metabolisms (CcpA …

In actinobacteria, an OmpR/PhoB subfamily protein called GlnR acts as an orphan response
regulator and globally coordinates the expression of genes responsible for nitrogen, carbon …

Streptomyces species are a wide and diverse source of many therapeutic agents
(antimicrobials, antineoplastic and antioxidants, to name a few) and represent an important …

GlnR, an OmpR-like orphan two-component system response regulator, is a master
regulator of nitrogen metabolism in the genus Streptomyces. In this work, evidence that GlnR …

Soil-dwelling Streptomyces bacteria such as S. coelicolor have to constantly adapt to the
nitrogen (N) availability in their habitat. Thus, strict transcriptional and post-translational …