Collisional unfolding of multiprotein complexes reveals cooperative stabilization upon ligand binding

S Niu, BT Ruotolo - Protein Science, 2015 - Wiley Online Library
Cooperative binding mechanisms are a common feature in biology, enabling a diverse
range of protein‐based molecular machines to regulate activities ranging from oxygen …

Top-down 193-nm ultraviolet photodissociation mass spectrometry for simultaneous determination of polyubiquitin chain length and topology

JR Cannon, K Martinez-Fonts, SA Robotham… - Analytical …, 2015 - ACS Publications
Protein ubiquitin modifications present a vexing analytical challenge, because of the
dynamic changes in the site of modification on the substrate, the number of ubiquitin …

PolyUbiquitin chain linkage topology selects the functions from the underlying binding landscape

Y Wang, C Tang, E Wang, J Wang - PLoS computational biology, 2014 - journals.plos.org
Ubiquitin (Ub) can generate versatile molecular signals and lead to different celluar fates.
The functional poly-valence of Ub is believed to be resulted from its ability to form distinct …

Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for use in mass spectrometry

S Trimpin, E Inutan, H Coffinberger… - … Journal of Mass …, 2023 - journals.sagepub.com
In remembrance of Prof. Dr Przybylski, we are presenting a vision towards his beloved mass
spectrometry (MS) and its far-reaching promises outside of the academic laboratory. Sub …

Quantitative Analysis of Diubiquitin Isomers Using Ion Mobility Mass Spectrometry

EI Shestoperova, DG Ivanov… - Journal of the American …, 2023 - ACS Publications
The diversity of ubiquitin modifications calls for methods to better characterize ubiquitin
chain linkage, length, and morphology. Here, we use multiple linear regression analysis …

Structural Insights into Linkage-Specific Ubiquitin Chains Using Ion Mobility Mass Spectrometry

JE Jung, MA Ewing, SJ Valentine… - Journal of the American …, 2024 - ACS Publications
The structural characterization and differentiation of four types of oligoubiquitin conjugates
[linear (Met1)-, Lys11-, Lys48-, Lys63-linked di-, tri-, and tetraubiquitin chains] using ion …

Temperature dependence of gas-phase conformations for ubiquitin ions characterized by proton transfer reactions

S Nonose, T Okamura, K Yamashita, A Sudo - Chemical Physics, 2013 - Elsevier
Proton transfer from multiply-protonated ubiquitin ions,[M+ zH]+ z (z= 6–12), to 1-butylamine
was studied in the gas phase. Absolute reaction rate constant for proton transfer was …

Ion mobility and Top-down MS complementary approaches for the structural analysis of protein models bound to anticancer metallodrugs

E Escribano, S Madurga, M Vilaseca, V Moreno - Inorganica Chimica Acta, 2014 - Elsevier
Interactions between proteins and platinum (Pt) compounds lie at the heart of both the
effectiveness of Pt-based drugs and their side effects. A greater understanding of such …

Conformational landscapes of rigid and flexible molecules explored with variable temperature ion mobility-mass spectrometry

X Wang, E Norgate, J Dai, F Benoit, J Kalapothakis… - 2024 - chemrxiv.org
Understanding the effect of temperature to the structural integrity and dynamics of proteins
has relevance for many areas including biotechnology and the maintenance of a stable food …

[PDF][PDF] Хронический H. Pylori-ассоциированный гастрит и MALT-лимфома желудка: клинико-диагностические особенности

ЮВ Косталанова - 2017 - samsmu.ru
H. pylori, являются одними из наиболее распространенных болезней человечества. К
H. pylori-ассоциированным болезням относятся хронический гастрит (ХГ), язвенная …