Current understanding of the pathogenesis of dengue virus infection

P Bhatt, SP Sabeena, M Varma, G Arunkumar - Current microbiology, 2021 - Springer
The pathogenesis of dengue virus infection is attributed to complex interplay between virus,
host genes and host immune response. Host factors such as antibody-dependent …

Dengue

A Wilder-Smith, EE Ooi, O Horstick, B Wills - The Lancet, 2019 - thelancet.com
Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

Meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections

KM Soo, B Khalid, SM Ching, HY Chee - PloS one, 2016 - journals.plos.org
Introduction Dengue virus (DENV) infection is currently a major cause of morbidity and
mortality in the world; it has become more common and virulent over the past half-century …

Insights into dengue immunity from vaccine trials

EE Ooi, S Kalimuddin - Science translational medicine, 2023 - science.org
The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …

Current status of dengue therapeutics research and development

JGH Low, EE Ooi, SG Vasudevan - The Journal of infectious …, 2017 - academic.oup.com
Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …

Dengue virus

A Murugesan, M Manoharan - Emerging and reemerging viral pathogens, 2020 - Elsevier
Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …

Serological cross-reactivity among common flaviviruses

KR Chan, AA Ismail, G Thergarajan, CS Raju… - Frontiers in Cellular …, 2022 - frontiersin.org
The Flavivirus genus is made up of viruses that are either mosquito-borne or tick-borne and
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …

The pathogenesis of dengue

J Whitehorn, CP Simmons - Vaccine, 2011 - Elsevier
Dengue is an important cause of childhood and adult morbidity in Asian and Latin American
countries and its geographic footprint is growing. The clinical manifestations of dengue are …

The good, the bad, and the shocking: the multiple roles of dengue virus nonstructural protein 1 in protection and pathogenesis

DR Glasner, H Puerta-Guardo, PR Beatty… - Annual review of …, 2018 - annualreviews.org
Dengue virus (DENV) is the most prevalent medically important mosquito-borne virus in the
world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found …

Contributions from the silent majority dominate dengue virus transmission

QA Ten Bosch, HE Clapham, L Lambrechts… - PLoS …, 2018 - journals.plos.org
Despite estimates that, each year, as many as 300 million dengue virus (DENV) infections
result in either no perceptible symptoms (asymptomatic) or symptoms that are sufficiently …