Current understanding of the pathogenesis of dengue virus infection
The pathogenesis of dengue virus infection is attributed to complex interplay between virus,
host genes and host immune response. Host factors such as antibody-dependent …
host genes and host immune response. Host factors such as antibody-dependent …
Meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections
Introduction Dengue virus (DENV) infection is currently a major cause of morbidity and
mortality in the world; it has become more common and virulent over the past half-century …
mortality in the world; it has become more common and virulent over the past half-century …
Insights into dengue immunity from vaccine trials
EE Ooi, S Kalimuddin - Science translational medicine, 2023 - science.org
The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …
another that has completed phase 3 clinical trials. However, shortcomings exist in each …
Current status of dengue therapeutics research and development
Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …
now available, which is a notable achievement, its long-term protective efficacy against each …
Dengue virus
A Murugesan, M Manoharan - Emerging and reemerging viral pathogens, 2020 - Elsevier
Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …
Serological cross-reactivity among common flaviviruses
The Flavivirus genus is made up of viruses that are either mosquito-borne or tick-borne and
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …
The pathogenesis of dengue
J Whitehorn, CP Simmons - Vaccine, 2011 - Elsevier
Dengue is an important cause of childhood and adult morbidity in Asian and Latin American
countries and its geographic footprint is growing. The clinical manifestations of dengue are …
countries and its geographic footprint is growing. The clinical manifestations of dengue are …
The good, the bad, and the shocking: the multiple roles of dengue virus nonstructural protein 1 in protection and pathogenesis
DR Glasner, H Puerta-Guardo, PR Beatty… - Annual review of …, 2018 - annualreviews.org
Dengue virus (DENV) is the most prevalent medically important mosquito-borne virus in the
world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found …
world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found …
Contributions from the silent majority dominate dengue virus transmission
Despite estimates that, each year, as many as 300 million dengue virus (DENV) infections
result in either no perceptible symptoms (asymptomatic) or symptoms that are sufficiently …
result in either no perceptible symptoms (asymptomatic) or symptoms that are sufficiently …