Insulin remains indispensable in the treatment of diabetes, but its use is hampered by its
narrow therapeutic index. Although advances in peptide chemistry and recombinant DNA …

Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …

Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning
numerous biological processes, has lately made its mark as a much sought-after therapeutic …

Growth factors modulate germ line stem cell self-renewal and differentiation behavior. We
investigate the effects of Igf3, a fish-specific member of the igf family. Fsh increased in a …

Persons with type 1 or type 2 diabetes have a significantly higher fracture risk than age‐
matched persons without diabetes, attributed to disease‐specific deficits in the …

The insulin receptor (IR) is a transmembrane protein that is activated by ligands in insulin
signaling pathways. The IR has been considered as a novel therapeutic target for clinical …

The insulin and insulin-like growth factor (IGF) system plays an important role in regulating
normal cell proliferation and survival. However, the IGF system is also implicated in many …

Scope We investigated whether rutin, a flavonoid isolated from Toona sinensis Roem, has
the ability to enhance insulin‐dependent receptor kinase (IRK) activity and glucose …

Phage display technology as a selection-based system is an attractive method for evolution
of new biological drugs. Unique ability of phage libraries for displaying proteins on …