Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

The conventional view of dendritic function is that dendrites collect synaptic input and deliver
it to the soma. This view has been challenged in recent years by new results demonstrating …

All cells use changes in intracellular calcium concentration ([Ca2+] i) to regulate cell
signalling events. In neurons, with their elaborate dendritic and axonal arborizations, there …

Signaling nanodomains rely on spatial organization of proteins to allow controlled
intracellular signaling. Examples include calcium release sites of cardiomyocytes where …

Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM),
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …

Filopodia are sensors on both excitable and non-excitable cells. The sensing function is well
documented in neurons and blood vessels of adult animals and is obvious during dorsal …

This is a book on mathematical neuroscience, in which the unifying theme is wavelike
phenomena at multiple spatial and temporal scales. There are already several excellent …

The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …

The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching
throughout the cell. Understanding how ER functionality relies on its structural organization …

Abstract Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain.
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …