Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The hedgehog (SHH) signaling pathway is primarily involved in embryonic gut development,
smooth muscle differentiation, cell proliferation, adult tissue homeostasis, tissue repair …

The leading cause of end-stage renal disease in children is attributed to congenital
anomalies of the kidney and urinary tract (CAKUT). Familial clustering and mouse models …

Congenital anomalies of the lower urinary tract (CALUT) are a family of birth defects of the
ureter, the bladder, and the urethra. CALUT includes ureteral anomaliesc such as congenital …

Renal cystic diseases are a leading cause of renal failure. Mutations associated with renal
cystic diseases reside in genes encoding proteins that localize to primary cilia. These …

The exponential rise in our understanding of the aetiology and pathophysiology of genetic
cystic kidney diseases can be attributed to the identification of cystogenic genes over the last …

Congenital obstructive uropathy, a major cause of chronic kidney disease, is defined as
kidney, ureter, and/or bladder injury associated with obstruction of the urinary tract …

Congenital anomalies of the kidney and urinary tract (CAKUTs) represent the leading cause
of chronic kidney disease and end-stage kidney disease in children. Increasing evidence …

The mammalian ureter is a slender tube that connects the renal pelvis with the bladder. It
allows the unidirectional movement of urine by means of a peristaltically active smooth …

The differentiated cell types of the epithelial and mesenchymal tissue compartments of the
mature ureter of the mouse arise in a precise temporal and spatial sequence from …