Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

Spreading depolarization is observed as a large negative shift of the direct current potential,
swelling of neuronal somas, and dendritic beading in the brain's gray matter and represents …

Mapping the entire frequency bandwidth of brain electrophysiological signals is of
paramount importance for understanding physiological and pathological states. The ability …

Spreading depolarizations are characterized by abrupt, near-complete breakdown of the
transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate …

In DISCHARGE-1, a recent Phase III diagnostic trial in aneurysmal subarachnoid
haemorrhage patients, spreading depolarization variables were found to be an independent …

While subarachnoid hemorrhage is the second most common hemorrhagic stroke in
epidemiologic studies, the recent DISCHARGE-1 trial has shown that in reality, three …

Background Both seizures and spreading depolarizations (SDs) are commonly detected
using electrocorticography (ECoG) after severe traumatic brain injury (TBI). A close …

Epilepsy is a serious neurological disorder which affects every aspect of patients' life,
including added socio-economic burden. Unfortunately, only a few suppressive medicines …

Background Spreading depolarization (SD) and the initial, still reversible phase of neuronal
cytotoxic edema in the cerebral gray matter are two modalities of the same process. SD may …

Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a
major health concern that often leads to long-lasting complications. However, the …