Clinical aspects of multiple endocrine neoplasia type 1

A Al-Salameh, G Cadiot, A Calender… - Nature Reviews …, 2021 - nature.com
Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the co-
occurrence of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumours …

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

MC Lemos, RV Thakker - Human mutation, 2008 - Wiley Online Library
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …

Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies

RT Jensen, MJ Berna, DB Bingham, JA Norton - Cancer, 2008 - Wiley Online Library
Pancreatic endocrine tumors (PETs) have long fascinated clini-cians, because some can
release biologically active hormones that cause distinct syndromes and provide important …

Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study

B Vergès, F Boureille, P Goudet, A Murat… - The Journal of …, 2002 - academic.oup.com
To date, data on pituitary adenomas in MEN type 1 (MEN1) still have to be evaluated. We
analyzed the data of a large series of 324 MEN1 patients from a French and Belgian …

Risk factors and causes of death in MEN1 disease. A GTE (Groupe d'Etude des Tumeurs Endocrines) cohort study among 758 patients

P Goudet, A Murat, C Binquet, C Cardot-Bauters… - World journal of …, 2010 - Springer
Background The natural history of multiple endocrine neoplasia type 1 (MEN1) is known
through single-institution or single-family studies. We aimed to analyze the risk factors and …

Highly penetrant hereditary cancer syndromes

R Nagy, K Sweet, C Eng - Oncogene, 2004 - nature.com
The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

MEN1 disease occurring before 21 years old: a 160-patient cohort study from the Groupe d'étude des Tumeurs Endocrines

P Goudet, A Dalac, M Le Bras… - The Journal of …, 2015 - academic.oup.com
Context: Multiple endocrine neoplasia Type-1 (MEN1) in young patients is only described by
case reports. Objective: To improve the knowledge of MEN1 natural history before 21 years …

Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with …

T Ito, H Igarashi, H Uehara, MJ Berna, RT Jensen - Medicine, 2013 - journals.lww.com
Multiple endocrine neoplasia type 1 (MEN1) is classically characterized by the development
of functional or nonfunctional hyperplasia or tumors in endocrine tissues (parathyroid …

HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours

VM Howell, CJ Haven, K Kahnoski, SK Khoo… - Journal of medical …, 2003 - jmg.bmj.com
Background: Hyperparathyroidism is a common endocrinopathy characterised by the
formation of parathyroid tumours. In this study, we determine the role of the recently …

Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: a prospective study of 107 cases and comparison with 1009 cases from the literature

F Gibril, M Schumann, A Pace, RT Jensen - Medicine, 2004 - journals.lww.com
In patients with multiple endocrine neoplasia type 1 (MEN1), the most common functional
pancreatic endocrine tumor (PET) syndrome is Zollinger-Ellison syndrome (ZES). ZES has …