Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …

Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

Abstract A new series of 1, 2, 4-oxadiazole incorporated indazole-isoxazole (12a–j)
derivatives were designed, synthesized and confirmed their structures by 1HNMR, 13CNMR …

In here, a series of pyrimidin-(1 (2 H)-yl) acetamide and pyrimidin-(1 (2 H)-yl) isophthalimide
derivatives were synthesised according to literature. The cytotoxic activity properties of these …

Chemotherapy is a critical treatment modality for cancer patients, but multidrug resistance
remains one of the major challenges in cancer therapy, creating an urgent need for the …

The thiazole ring is naturally occurring and is primarily found in marine and microbial
sources. It has been identified in various compounds such as peptides, vitamins (thiamine) …

In this study, a novel series of pyrimidine compounds featuring azo linkages was
synthesized via a sequence of stepwise and one-pot three-component reactions. The …

To underscore the significance of thiazole and thiadiazole moieties in advancing cancer
treatment and support researchers in drug design, we developed a novel series of 1, 3, 4 …

A series of benzothiazolopyrimidine-thiazole conjugates 7, 8, and 9 were produced through
the reactions of 8-acetylbenzothiazolopyrimidine-thiosemicarbazone compound 6 with …

This study deals with the design and synthesis of new pyrazoline-thiazole scaffold as
promising anti-cancer agents, with the goal of building new compounds with combinations of …