The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …
considered only as pathological aggregates implicated in human neurodegenerative …
The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo… - Nature reviews Molecular …, 2014 - nature.com
The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …
rapidly increasing research activities across a wide range of scientific disciplines. Such …
Molecular mechanisms of protein aggregation from global fitting of kinetic models
The elucidation of the molecular mechanisms by which soluble proteins convert into their
amyloid forms is a fundamental prerequisite for understanding and controlling disorders that …
amyloid forms is a fundamental prerequisite for understanding and controlling disorders that …
On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse - Physical Chemistry Chemical Physics, 2015 - pubs.rsc.org
The formation of nanoscale amyloid fibrils from normally soluble peptides and proteins is a
common form of self-assembly phenomenon that has fundamental connections with …
common form of self-assembly phenomenon that has fundamental connections with …
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
Alzheimer's disease is a neurodegenerative disorder associated with the aberrant
aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol …
aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol …
The role of lipids interacting with α-synuclein in the pathogenesis of Parkinson's disease
C Galvagnion - Journal of Parkinson's disease, 2017 - content.iospress.com
Abstract α-synuclein is a small protein abundantly expressed in the brain and mainly located
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …
Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation
Understanding how normally soluble peptides and proteins aggregate to form amyloid fibrils
is central to many areas of modern biomolecular science, ranging from the development of …
is central to many areas of modern biomolecular science, ranging from the development of …
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
P Arosio, TCT Michaels, S Linse, C Månsson… - Nature …, 2016 - nature.com
It is increasingly recognized that molecular chaperones play a key role in modulating the
formation of amyloid fibrils, a process associated with a wide range of human disorders …
formation of amyloid fibrils, a process associated with a wide range of human disorders …
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in
Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate …
Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate …