Role and mechanism of action of sclerostin in bone
After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …
human syndromes Van Buchem disease and sclerosteosis, extensive animal …
The role of sclerostin in bone diseases
ES Vasiliadis, DS Evangelopoulos, A Kaspiris… - Journal of clinical …, 2022 - mdpi.com
Sclerostin has been identified as an important regulator of bone homeostasis through
inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of …
inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of …
Sclerostin deficiency in humans
AH van Lierop, NM Appelman-Dijkstra, SE Papapoulos - Bone, 2017 - Elsevier
Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by
genetic defects in the synthesis of sclerostin. In this article we review the demographic …
genetic defects in the synthesis of sclerostin. In this article we review the demographic …
Hormonal and systemic regulation of sclerostin
MT Drake, S Khosla - Bone, 2017 - Elsevier
The Wnt/β-catenin signaling pathway plays an essential role in osteoblast biology.
Sclerostin is a soluble antagonist of Wnt/β-catenin signaling secreted primarily by …
Sclerostin is a soluble antagonist of Wnt/β-catenin signaling secreted primarily by …
Sclerostin: from molecule to clinical biomarker
A Omran, D Atanasova, F Landgren… - International Journal of …, 2022 - mdpi.com
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature
osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt …
osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt …
[HTML][HTML] Vitamin D–regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification
L Nguyen-Yamamoto, KI Tanaka, R St–Arnaud… - JCI insight, 2019 - ncbi.nlm.nih.gov
We induced chronic kidney disease (CKD) with adenine in WT mice, mice with osteocyte-
specific deletion of Cyp27b1, encoding the 25-hydroxyvitamin D 1 (OH) ase [Oct-1 (OH) ase …
specific deletion of Cyp27b1, encoding the 25-hydroxyvitamin D 1 (OH) ase [Oct-1 (OH) ase …
Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone—Vascular paradox, a …
MJ Williams, SC White, Z Joseph, KA Hruska - Frontiers in Physiology, 2023 - frontiersin.org
The chronic kidney disease-mineral bone disorder (CKD-MBD) is a complex multi-
component syndrome occurring during kidney disease and its progression. Here, we update …
component syndrome occurring during kidney disease and its progression. Here, we update …
Calcium and vitamin D supplementation and bone health in Marine recruits: effect of season
E Gaffney-Stomberg, AT Nakayama, KI Guerriere… - Bone, 2019 - Elsevier
Stress fractures are common overuse injuries caused by repetitive bone loading. These
fractures are of particular concern for military recruits and athletes resulting in attrition in up …
fractures are of particular concern for military recruits and athletes resulting in attrition in up …
Both ligand and VDR expression levels critically determine the effect of 1α, 25-dihydroxyvitamin-D3 on osteoblast differentiation
Previous studies have shown that 1α, 25-dihydroxyvitamin D 3 (1, 25D) through vitamin D
receptor (VDR) signalling has both catabolic and anabolic effects on osteoblast …
receptor (VDR) signalling has both catabolic and anabolic effects on osteoblast …
Exploiting the WNT signaling pathway for clinical purposes
ML Johnson, RR Recker - Current osteoporosis reports, 2017 - Springer
Abstract Purpose of Review The goal of this paper is to evaluate critically the literature
published over the past 3 years regarding the Wnt signaling pathway. The Wnt pathway was …
published over the past 3 years regarding the Wnt signaling pathway. The Wnt pathway was …