During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

Estrogen receptor beta (ER-β) regulates diverse physiological functions in the human body.
Current studies are confined to ER-β1, and the functional roles of isoforms 2, 4, and 5 …

The discovery of a second estrogen receptor (ER), designated ERβ (NR3A2), has redefined
our knowledge about the mechanisms underlying cellular signaling by estrogens and has …

Purpose: Previous conflicting results about the prognostic significance of estrogen receptor
(ER)-β in breast cancer may be explained by contribution of isoforms, of which five exist. Our …

Triple negative breast cancer (TNBC) is a type of aggressive breast cancer lacking the
expression of estrogen receptors (ER), progesterone receptors (PR) and human epidermal …

Identification of molecular alterations in key proteins involved in breast cancer cell
proliferation and survival resulted in the development of a new treatment strategy with target …

Estrogens regulate growth and development through the action of two distinct estrogen
receptors (ERs), ERα and ERβ, which mediate proliferation and differentiation of cells. For …

The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the
diagnostics and therapy of different types of cancer. Here, we present a review of the present …

Despite the existence of many promising anti-cancer therapies, not all breast cancers are
equally treatable, due partly to the fact that focus has been primarily on a few select breast …