Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …

IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives

C Mancarella, K Scotlandi - Frontiers in cell and developmental …, 2020 - frontiersin.org
RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

The roles of insulin‐like growth factor 2 mRNA‐binding protein 2 in cancer and cancer stem cells

J Cao, Q Mu, H Huang - Stem cells international, 2018 - Wiley Online Library
RNA‐binding proteins (RBPs) mediate the localization, stability, and translation of the target
transcripts and fine‐tune the physiological functions of the proteins encoded. The insulin …

Insulin-like growth factor II-messenger RNA-binding protein-3 and lung cancer

JJ Findeis-Hosey, H Xu - Biotechnic & Histochemistry, 2012 - Taylor & Francis
Insulin-like growth factor II-messenger RNA-binding protein 3 (IMP3) is an oncofetal RNA-
binding protein that promotes tumor cell proliferation by enhancing IGF-II protein synthesis …

Oncofetal protein IMP3, a new cancer biomarker

Y Gong, BA Woda, Z Jiang - Advances in anatomic pathology, 2014 - journals.lww.com
IMP3 is a member of a family of RNA-binding proteins that consists of IMP1, IMP2 and IMP3.
These proteins contain 2 RNA recognition motifs and 4 K-homology domains that allow them …

Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study

Z Jiang, PG Chu, BA Woda, KL Rock, Q Liu… - The lancet …, 2006 - thelancet.com
Background Distant metastasis is the main cause of death from renal-cell carcinoma, and
the metastatic potential of tumours is often unpredictable. We aimed to investigate whether …

IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

Y Zhou, T Huang, HL Siu, CC Wong, Y Dong, F Wu… - Molecular cancer, 2017 - Springer
Background Gastric cancer (GC) is one of the frequent causes of cancer-related death in
eastern Asian population. IGF2BP2 lists in the top rank up-regulated genes in GC, but its …

Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma

RH Yuan, CC Wang, CC Chou, KJ Chang… - Annals of surgical …, 2009 - Springer
Background IMP3 (insulinlike growth factor II mRNA-binding protein 3) is a newly identified
oncofetal RNA-binding protein that is involved in cell growth and cell migration during the …

Insulin‐like growth factor II mRNA‐binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma

ST Chen, YM Jeng, CC Chang, HH Chang… - Cancer …, 2011 - Wiley Online Library
Insulin‐like growth factor II mRNA‐binding protein 3 (IMP3) has been reported to enhance
proliferation and invasion in various cancers. The role of IMP3 on neuroblastoma (NB) is …

[HTML][HTML] Expression of insulin-like growth factor II mRNA-binding protein 3 predicts early recurrence and poor prognosis in intrahepatic cholangiocarcinoma

YL Chen, YM Jeng, HC Hsu, HS Lai, PH Lee… - International Journal of …, 2013 - Elsevier
INTRODUCTION: Insulin-like growth factor-II mRNA-binding protein 3 (IMP3), a newly
identified oncofetal RNA-binding protein, plays a pivotal role in the regulation of cell growth …