Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats
Background Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally
prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has …
prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has …
Shikonin alleviates gentamicin-induced renal injury in rats by targeting renal endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt cascades
Gentamicin causes kidney injury due to its accumulation in proximal tubule epithelial cells
via the megalin/cubilin/CLC-5 complex. Recently, shikonin has been shown to have …
via the megalin/cubilin/CLC-5 complex. Recently, shikonin has been shown to have …
Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway
L Li, K Zhao, J Luo, J Tian, F Zheng, X Lin… - Journal of Agricultural …, 2024 - ACS Publications
Uncontrolled hyperuricemia often leads to the development of hyperuricemic nephropathy
(HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic …
(HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic …
Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF-κB/NLRP3/GSDMD signaling pathways
Diclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction
and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug …
and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug …
Protective role of melatonin against diclofenac-induced acute kidney injury
SM El Agaty, S Khedr, DKM Mostafa, NA Wanis… - Life Sciences, 2024 - Elsevier
Abstract Diclofenac (DF), a non-steroidal anti-inflammatory drug, is commonly used to
relieve pain and inflammation. High doses of DF might induce acute kidney injury (AKI) …
relieve pain and inflammation. High doses of DF might induce acute kidney injury (AKI) …
[HTML][HTML] 6-Paradol Alleviates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Inhibiting AKT/mTOR Axis
LS Binmahfouz, H Almukadi, AJ Alamoudi… - Plants, 2022 - mdpi.com
Introduction: Benign prostatic hyperplasia (BPH) is a common disease among elderly men.
Its pharmacological treatment is still unsatisfactory. 6-Paradol (6-PD) is an active metabolite …
Its pharmacological treatment is still unsatisfactory. 6-Paradol (6-PD) is an active metabolite …
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
M Chen, J Lv, N Guo, T Ji, Y Fang, Z Wang, X He - Journal of Inflammation, 2024 - Springer
Background Interplay between systemic inflammation and programmed cell death
contributes to the pathogenesis of acute lung injury (ALI). cAMP-regulated transcriptional …
contributes to the pathogenesis of acute lung injury (ALI). cAMP-regulated transcriptional …
Screening of the key response component groups and mechanism verification of Huangqi-Guizhi-Wuwu-Decoction in treating rheumatoid arthritis based on a novel …
Q Liu, Q Luo, Q Fan, Y Li, A Lu, D Guan - BMC Complementary Medicine …, 2024 - Springer
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by
the destruction of synovial tissue and articular cartilage. Huangqi-Guizhi-Wuwu-Decoction …
the destruction of synovial tissue and articular cartilage. Huangqi-Guizhi-Wuwu-Decoction …
[HTML][HTML] The Molecular Mechanism and Therapeutic Strategy of Cardiorenal Syndrome Type 3
Y Liu, X Guan, Y Shao, J Zhou… - Reviews in Cardiovascular …, 2023 - imrpress.com
Cardiorenal syndrome type 3 (CRS3) is defined as acute kidney injury (AKI)-induced acute
cardiac dysfunction, characterized by high morbidity and mortality. CRS3 often occurs in …
cardiac dysfunction, characterized by high morbidity and mortality. CRS3 often occurs in …
[PDF][PDF] 6-Paradol Alleviates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Inhibiting AKT/mTOR Axis. Plants 2022, 11, 2602
LS Binmahfouz, H Almukadi, AJ Alamoudi… - 2022 - academia.edu
Introduction: Benign prostatic hyperplasia (BPH) is a common disease among elderly men.
Its pharmacological treatment is still unsatisfactory. 6-Paradol (6-PD) is an active metabolite …
Its pharmacological treatment is still unsatisfactory. 6-Paradol (6-PD) is an active metabolite …