Therapeutic targeting of the DNA mismatch repair pathway
SA Martin, CJ Lord, A Ashworth - Clinical cancer research, 2010 - AACR
The mismatch repair (MMR) pathway is involved in the removal of DNA base mismatches
that arise either during DNA replication or are caused by DNA damage. Mutations in four …
that arise either during DNA replication or are caused by DNA damage. Mutations in four …
DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data
LM Martin, B Marples, M Coffey, M Lawler… - Cancer treatment …, 2010 - Elsevier
The DNA mismatch repair (MMR) pathway detects and repairs DNA replication errors. While
DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA …
DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA …
Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA …
W Wilczak, S Rashed, C Hube-Magg, M Kluth… - …, 2017 - academic.oup.com
DNA mismatch repair (MMR) is integral to the maintenance of genetic stability. We aimed to
evaluate the clinical impact of MMR gene expression in prostate cancer. The MMR genes …
evaluate the clinical impact of MMR gene expression in prostate cancer. The MMR genes …
Expressional analysis of MLH1 and MSH2 in breast cancer
Background Mismatch repair proteins are ubiquitous keys in diverse cellular functions and
protects the genome by correcting mismatch as post replication error correction machinery …
protects the genome by correcting mismatch as post replication error correction machinery …
Deregulated estrogen receptor signaling and DNA damage response in breast tumorigenesis
Carriers of BRCA1 mutations have a higher chance of developing cancers in hormone-
responsive tissues like the breast, ovary and prostate, compared to other tissues. These …
responsive tissues like the breast, ovary and prostate, compared to other tissues. These …
[HTML][HTML] Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights
Gliomas are highly invasive brain tumours characterised by poor prognosis and limited
response to therapy. There is an ongoing debate on the therapeutic potential of vaso …
response to therapy. There is an ongoing debate on the therapeutic potential of vaso …
[HTML][HTML] Effect of ubiquitin protease system on DNA damage response in prostate cancer
Y Lin, X Jin - Experimental and Therapeutic Medicine, 2024 - spandidos-publications.com
Genomic instability is an essential hallmark of cancer, and cellular DNA damage response
(DDR) defects drive tumorigenesis by disrupting genomic stability. Several studies have …
(DDR) defects drive tumorigenesis by disrupting genomic stability. Several studies have …
DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human …
Prolonged exposure to elevated levels of estrogen is a risk factor for breast cancer. Though
increased cell growth and loss of DNA repair capacity is one of the proposed mechanisms …
increased cell growth and loss of DNA repair capacity is one of the proposed mechanisms …
[HTML][HTML] The impact of HER2-low status on response to neoadjuvant chemotherapy in clinically HER2-negative breast cancer
W Wang, T Zhu, H Chen, Y Yao - Clinical and Translational Oncology, 2023 - Springer
Purpose Low expression of HER2 (HER2-low expression) in breast cancer (BC) has unique
biological characteristics. However, whether HER2-low expression has an impact on …
biological characteristics. However, whether HER2-low expression has an impact on …
[HTML][HTML] The convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancer
HQ Ta, D Gioeli - Endocrine-related cancer, 2014 - erc.bioscientifica.com
It is increasingly clear that castration-resistant prostate cancer (PCa) is dependent on the
androgen receptor (AR). This has led to the use of anti-androgen therapies that reduce …
androgen receptor (AR). This has led to the use of anti-androgen therapies that reduce …