[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Arrhythmogenic potential of myocardial disarray in hypertrophic cardiomyopathy: genetic basis, functional consequences and relation to sudden cardiac death

G Finocchiaro, N Sheikh, O Leone, J Westaby… - EP …, 2021 - academic.oup.com
Myocardial disarray is defined as disorganized cardiomyocyte spatial distribution, with loss
of physiological fibre alignment and orientation. Since the first pathological descriptions of …

Aberrant glycosylation in the left ventricle and plasma of rats with cardiac hypertrophy and heart failure

C Nagai-Okatani, N Minamino - PLoS One, 2016 - journals.plos.org
Targeted proteomics focusing on post-translational modifications, including glycosylation, is
a useful strategy for discovering novel biomarkers. To apply this strategy effectively to …

Uremic toxins in chronic kidney disease highlight a fundamental gap in understanding their detrimental effects on cardiac electrophysiology and arrhythmogenesis

WB van Ham, CM Cornelissen… - Acta …, 2022 - Wiley Online Library
Chronic kidney disease (CKD) and cardiovascular disease (CVD) have an estimated 700–
800 and 523 million cases worldwide, respectively, with CVD being the leading cause of …

Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish

R Okamoto, I Goto, Y Nishimura, I Kobayashi… - PLoS …, 2020 - journals.plos.org
Aims GJB4 encodes a transmembrane connexin protein (Cx30. 3) that is a component of
gap junctions. This study investigated whether GJB4 plays an important role in human heart …

Triptolide upregulates myocardial forkhead helix transcription factor p3 expression and attenuates cardiac hypertrophy

YY Ding, JM Li, FJ Guo, Y Liu, YF Tong… - Frontiers in …, 2016 - frontiersin.org
The forkhead/winged helix transcription factor (Fox) p3 can regulate the expression of
various genes, and it has been reported that the transfer of Foxp3-positive T cells could …

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of …

W Wang, S Ye, L Zhang, Q Jiang, J Chen… - BMC Cardiovascular …, 2020 - Springer
Background Coronary microembolization (CME) has a poor prognosis, with ventricular
arrhythmia being the most serious consequence. Understanding the underlying …

Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

L García-Mendívil, M Pérez-Zabalza, A Oliver-Gelabert… - Research, 2023 - spj.science.org
Connexin 43 (CX43) is one of the major components of gap junctions, the structures
responsible for the intercellular communication and transmission of the electrical impulse in …

Texture analysis of SPECT myocardial perfusion provides prognostic value for dilated cardiomyopathy

C Wang, Y Ma, Y Liu, L Li, C Cui, H Qin, Z Zhao… - Journal of Nuclear …, 2023 - Elsevier
Background Texture analysis (TA) has demonstrated clinical values in extracting
information, quantifying inhomogeneity, evaluating treatment outcomes, and predicting long …

Localisation microscopy of breast epithelial ErbB-2 receptors and gap junctions: Trafficking after γ-irradiation, neuregulin-1β, and trastuzumab application

G Pilarczyk, I Nesnidal, M Gunkel, M Bach… - International Journal of …, 2017 - mdpi.com
In cancer, vulnerable breast epithelium malignance tendency correlates with number and
activation of ErbB receptor tyrosine kinases. In the presented work, we observe ErbB …