How alcohol drinking affects our genes: an epigenetic point of view
This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism,
which is a complex multifactorial disorder. There is a large body of evidence showing that …
which is a complex multifactorial disorder. There is a large body of evidence showing that …
MeCP2 deficiency in neuroglia: new progress in the pathogenesis of Rett syndrome
XR Jin, XS Chen, L Xiao - Frontiers in molecular neuroscience, 2017 - frontiersin.org
Rett syndrome (RTT) is an X-linked neurodevelopmental disease predominantly caused by
mutations of the methyl-CpG-binding protein 2 (MeCP2) gene. Generally, RTT has been …
mutations of the methyl-CpG-binding protein 2 (MeCP2) gene. Generally, RTT has been …
A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder
Autism spectrum disorder (ASD) is genetically heterogeneous with convergent
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination
The function of poly (ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination
of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an …
of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an …
RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome
NL Pacheco, MR Heaven, LM Holt, DK Crossman… - Molecular autism, 2017 - Springer
Background Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by
mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 …
mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 …
Changes in the cerebrospinal fluid and plasma lipidome in patients with Rett syndrome
M Zandl-Lang, T Züllig, M Trötzmüller, Y Naegelin… - Metabolites, 2022 - mdpi.com
Rett syndrome (RTT) is defined as a rare disease caused by mutations of the methyl-CpG
binding protein 2 (MECP2). It is one of the most common causes of genetic mental …
binding protein 2 (MECP2). It is one of the most common causes of genetic mental …
Epigenetic control of oligodendrocyte development: adding new players to old keepers
Highlights•Most epigenetic events regulating OPC differentiation repress
transcription.•Extrinsic cues initiate epigenetic changes in OPCs leading to differentiation.• …
transcription.•Extrinsic cues initiate epigenetic changes in OPCs leading to differentiation.• …
MECP2 and the biology of MECP2 duplication syndrome
SR D'Mello III - Journal of Neurochemistry, 2021 - Wiley Online Library
Abstract MECP2 duplication syndrome (MDS), a rare X‐linked genomic disorder affecting
predominantly males, is caused by duplication of the chromosomal region containing the …
predominantly males, is caused by duplication of the chromosomal region containing the …
Glial dysfunction in MeCP2 deficiency models: implications for Rett syndrome
U Kahanovitch, KC Patterson, R Hernandez… - International Journal of …, 2019 - mdpi.com
Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting
females, resulting in a range of symptoms including autistic features, intellectual impairment …
females, resulting in a range of symptoms including autistic features, intellectual impairment …
Differential brain region‐specific expression of MeCP2 and BDNF in Rett Syndrome patients: a distinct grey‐white matter variation
S Pejhan, VM Siu, LC Ang… - Neuropathology and …, 2020 - Wiley Online Library
Introduction and objectives Rett Syndrome (RTT) is a neurodevelopmental disorder caused
by Methyl CpG Binding Protein 2 (MECP2) gene mutations. Previous studies of MeCP2 in …
by Methyl CpG Binding Protein 2 (MECP2) gene mutations. Previous studies of MeCP2 in …