Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii

TS Lima, MB Lodoen - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Toxoplasma gondii is an intracellular protozoan parasite of global importance that can
remarkably infect, survive, and replicate in nearly all mammalian cells. Notably, 110 years …

The pathogenicity and virulence of Toxoplasma gondii

SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

Salmonella effector SteE converts the mammalian serine/threonine kinase GSK3 into a tyrosine kinase to direct macrophage polarization

I Panagi, E Jennings, J Zeng, RA Günster, CD Stones… - Cell host & …, 2020 - cell.com
Many Gram-negative bacterial pathogens antagonize anti-bacterial immunity through
translocated effector proteins that inhibit pro-inflammatory signaling. In addition, the …

In vivo CRISPR screen identifies TgWIP as a Toxoplasma modulator of dendritic cell migration

LO Sangaré, EB Ólafsson, Y Wang, N Yang, L Julien… - Cell host & …, 2019 - cell.com
Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic
phase. However, genes involved in related in vivo processes are currently unknown. Here …

[HTML][HTML] The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

AL Ten Hoeve, L Braun, ME Rodriguez, GC Olivera… - Cell host & …, 2022 - cell.com
Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …

Dense granule biogenesis, secretion, and function in Toxoplasma gondii

MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …

High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription

S Butterworth, K Kordova, S Chandrasekaran… - Cell Host & Microbe, 2023 - cell.com
Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

A Rosenberg, LD Sibley - Cell host & microbe, 2021 - cell.com
Toxoplasma gondii translocates effector proteins into its host cell to subvert various host
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …