Toxoplasma gondii infection and its implications within the central nervous system
SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …
infections in humans. Although it normally only results in mild illness in healthy individuals …
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them
EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …
system to investigate how the immune system deals with intracellular infections. This review …
Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii
TS Lima, MB Lodoen - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Toxoplasma gondii is an intracellular protozoan parasite of global importance that can
remarkably infect, survive, and replicate in nearly all mammalian cells. Notably, 110 years …
remarkably infect, survive, and replicate in nearly all mammalian cells. Notably, 110 years …
The pathogenicity and virulence of Toxoplasma gondii
SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …
ranging from birds to humans. While this infection is usually asymptomatic in healthy …
Salmonella effector SteE converts the mammalian serine/threonine kinase GSK3 into a tyrosine kinase to direct macrophage polarization
I Panagi, E Jennings, J Zeng, RA Günster, CD Stones… - Cell host & …, 2020 - cell.com
Many Gram-negative bacterial pathogens antagonize anti-bacterial immunity through
translocated effector proteins that inhibit pro-inflammatory signaling. In addition, the …
translocated effector proteins that inhibit pro-inflammatory signaling. In addition, the …
In vivo CRISPR screen identifies TgWIP as a Toxoplasma modulator of dendritic cell migration
Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic
phase. However, genes involved in related in vivo processes are currently unknown. Here …
phase. However, genes involved in related in vivo processes are currently unknown. Here …
[HTML][HTML] The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages
AL Ten Hoeve, L Braun, ME Rodriguez, GC Olivera… - Cell host & …, 2022 - cell.com
Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …
Dense granule biogenesis, secretion, and function in Toxoplasma gondii
MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …
High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …
Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis
A Rosenberg, LD Sibley - Cell host & microbe, 2021 - cell.com
Toxoplasma gondii translocates effector proteins into its host cell to subvert various host
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …