Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Phagocytic cells of the immune system must constantly survey for, recognize, and efficiently
clear the billions of cellular corpses that arise as a result of development, stress, infection, or …

Bats are special in their ability to host emerging viruses. As the only flying mammal, bats
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …

Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. By
generation of mice in which inflammasome expression is restricted to IECs, we describe a …

The gut mucosal epithelium separates the host from the microbiota, but enteropathogens
such as Salmonella Typhimurium (S. Tm) can invade and breach this barrier. Defenses …

A limit to the clinical benefit of radiotherapy is not an incapacity to eliminate tumor cells but
rather a limit on its capacity to do so without destroying normal tissue and inducing …

We have recently highlighted (and added to) the considerable evidence that blood can
contain dormant bacteria. By definition, such bacteria may be resuscitated (and thus …

The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …

Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in
phagocytes and causes Legionnaires' disease. Upon infection of mammalian macrophages …

Cadmium (Cd) is an important and common environmental pollutant that has been linked to
cardiovascular diseases, such as atherosclerosis and hypertension. Increasing evidence …