The initiation of eukaryotic DNA replication
A Costa, JFX Diffley - Annual review of biochemistry, 2022 - annualreviews.org
DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
Origins of DNA replication in eukaryotes
Y Hu, B Stillman - Molecular cell, 2023 - cell.com
Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
A general method to fine-tune fluorophores for live-cell and in vivo imaging
JB Grimm, AK Muthusamy, Y Liang, TA Brown… - Nature …, 2017 - nature.com
Pushing the frontier of fluorescence microscopy requires the design of enhanced
fluorophores with finely tuned properties. We recently discovered that incorporation of four …
fluorophores with finely tuned properties. We recently discovered that incorporation of four …
Chromosome Duplication in Saccharomyces cerevisiae
SP Bell, K Labib - Genetics, 2016 - academic.oup.com
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
Eukaryotic DNA replication fork
PMJ Burgers, TA Kunkel - Annual review of biochemistry, 2017 - annualreviews.org
This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
Mechanisms for initiating cellular DNA replication
F Bleichert, MR Botchan, JM Berger - Science, 2017 - science.org
BACKGROUND Cellular life depends on the ability of organisms to accurately duplicate and
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
In preparation for bidirectional DNA replication, the origin recognition complex (ORC) loads
two hexameric MCM helicases to form a head-to-head double hexamer around DNA,. The …
two hexameric MCM helicases to form a head-to-head double hexamer around DNA,. The …
Mechanisms and regulation of DNA replication initiation in eukaryotes
MW Parker, MR Botchan, JM Berger - Critical reviews in …, 2017 - Taylor & Francis
Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
General synthetic method for Si-fluoresceins and Si-rhodamines
JB Grimm, TA Brown, AN Tkachuk… - ACS Central Science, 2017 - ACS Publications
The century-old fluoresceins and rhodamines persist as flexible scaffolds for fluorescent and
fluorogenic compounds. Extensive exploration of these xanthene dyes has yielded general …
fluorogenic compounds. Extensive exploration of these xanthene dyes has yielded general …
Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation
The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …