Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
family, are multifunctional cytokines. BMPs have a broad range of functions, and …

Parenteral sustained release drug formulations, acting as preferable platforms for long-term
exposure therapy, have been wildly used in clinical practice. However, most of these …

Resistance to immune checkpoint inhibitors (ICIs) is a common predicament in cancer
immunotherapy, which requires urgent interventions. V-domain immunoglobulin suppressor …

Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the
composition of the tumor microenvironment. Gene expression identified a high myeloid …

The immune checkpoint blockade therapy has completely transformed cancer treatment
modalities because of its unprecedented and durable clinical responses in various cancers …

Bone morphogenetic proteins (BMPs) are potent signaling molecules initially described as
osteopromoting proteins. BMPs represent one of the members of the larger TGFβ family and …

Diverse factors contribute to the limited clinical response to radiotherapy (RT) and
immunotherapy in metastatic non–small cell lung cancer (NSCLC), among which is the …

The field of oncology has been transformed by immune checkpoint inhibitors (ICI) and other
immune-based agents; however, many patients do not receive a durable benefit. While …

Damaged cartilage is seen with increasing frequency after joint trauma, alone or in
combination with other joint injuries. A poor healing of injured cartilage leads to great …