The over expression of EGFR has been recognized as the driver mechanism in the
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

The epidermal growth factor receptor (EGFR) plays a critical role in the tumorigenesis of
various forms of cancer. Targeting the mutant forms of EGFR has been identified as an …

Abstract Multi-target EGFR, HER2, VEGFR-2 and PDGFR is an improved strategy for the
treatment of solid tumors. This work deals with synthesis of an array of new 6-benzoyl …

Background: Epidermal Growth Factor Receptor (EGFR) and vascular endothelial growth
factor receptor (VEGFR) are responsible for several pathological conditions such as the …

Cancer is a multifactorial chronic disease cohorted with different protein kinases. Epidermal
growth factor receptor (EGFR) is the ligand-gated ion channel receptor or protein kinase …

News series of substituted quinazoline derivatives has been synthesized from 3, 4-dihydro-7-
methoxy-4-oxoquinazoline-6-yl acetate (1) by five-step procedures including chlorination …

Background: A wide range of pyrazole derivatives gained special attention due to their wide
range of pharmacological activities especially the therapeutic activities. Many …

Background: Breast cancer is the highest mortality-causing disease among cancers in
women and it can be cured by early diagnosis as well as treatment. Epidermal growth factor …

A new series of derivatives of N, 2-diphenylquinazolin-4-amine (3a-g) was synthesized
through nucleophilic substitution. The structures of compounds were characterized by FTIR …