Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

Introduction Restoration of blood flow following ischemic stroke can be achieved by means
of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may …

Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …

As a sequel of brain ischemia, selective neuronal loss (SNL)—as opposed to pannecrosis
(ie infarction)—is attracting growing interest, particularly because it is now detectable in vivo …

Water diffusion in brain tissue is affected by the presence of barriers to translational motion
such as cell membranes and myelin fibers. The measured water apparent diffusion …

After middle cerebral artery occlusion (MCAO) in the laboratory animal, the ischemic
penumbra has been documented as a severely hypoperfused, functionally impaired, but still …

Background MRI-based selection of patients for acute stroke interventions requires rapid
accurate estimation of the infarct core on diffusion-weighted MRI. Typically used manual …

Background and Purpose—With the advent of thrombolytic therapy for acute stroke,
reperfusion-associated mechanisms of tissue injury have assumed greater importance. In …

Over the last decade, several papers have focused on the construction of highly detailed
mouse high field magnetic resonance image (MRI) templates via non-linear registration to …

Diffusion-weighted imaging (DWI) is commonly used to assess irreversibly infarcted tissue
but its accuracy is challenged by reports of diffusion lesion reversal (DLR). We investigated …