GnRH replacement rescues cognition in Down syndrome

M Manfredi-Lozano, V Leysen, M Adamo, I Paiva… - Science, 2022 - science.org
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

[HTML][HTML] Astrocytes in Down syndrome across the lifespan

B Ponroy Bally, KK Murai - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Down Syndrome (DS) is the most common genetic cause of intellectual disability in which
delays and impairments in brain development and function lead to neurological and …

[HTML][HTML] Craniofacial morphology in down syndrome: a systematic review and meta-analysis

A Vicente, LA Bravo-González, A López-Romero… - Scientific Reports, 2020 - nature.com
The aim of this study was to evaluate the craniofacial cephalometric characteristics of
individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic …

[HTML][HTML] Cognitive profiles in children and adolescents with Down syndrome

S Onnivello, F Pulina, C Locatelli, C Marcolin… - Scientific Reports, 2022 - nature.com
The Down syndrome (DS) phenotype is usually characterized by relative strengths in non-
verbal skills and deficits in verbal processing, but high interindividual variability has been …

[HTML][HTML] Early alterations in cortical and cerebellar regional brain growth in Down Syndrome: An in vivo fetal and neonatal MRI assessment

PA Patkee, AA Baburamani, V Kyriakopoulou… - NeuroImage: Clinical, 2020 - Elsevier
Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide
spectrum of neurodevelopmental outcomes. At present, the relationship between structural …

[HTML][HTML] Competition between proton transfer and intermolecular Coulombic decay in water

C Richter, D Hollas, CM Saak, M Förstel… - Nature …, 2018 - nature.com
Intermolecular Coulombic decay (ICD) is a ubiquitous relaxation channel of electronically
excited states in weakly bound systems, ranging from dimers to liquids. As it is driven by …

[HTML][HTML] Down syndrome is an oxidative phosphorylation disorder

MP Bayona-Bafaluy, N Garrido-Pérez, P Meade… - Redox Biology, 2021 - Elsevier
Down syndrome is the most common genomic disorder of intellectual disability and is
caused by trisomy of chromosome 21. Several genes in this chromosome repress …

[HTML][HTML] Assessment of radial glia in the frontal lobe of fetuses with Down syndrome

AA Baburamani, RT Vontell, A Uus, M Pietsch… - Acta neuropathologica …, 2020 - Springer
Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated
with deviations in cortical development evidenced by simplified gyral appearance and …

[HTML][HTML] The role of oxidative stress in trisomy 21 phenotype

A Buczyńska, I Sidorkiewicz, AJ Krętowski… - Cellular and Molecular …, 2023 - Springer
Extensive research has been conducted to gain a deeper understanding of the deregulated
metabolic pathways in the development of trisomy 21 (T21) or Down syndrome. This …

[HTML][HTML] Gestational age is related to symptoms of attention-deficit/hyperactivity disorder in late-preterm to full-term children and adolescents with down syndrome

L del Hoyo Soriano, T Rosser, D Hamilton, T Wood… - Scientific Reports, 2020 - nature.com
Attention-deficit/hyperactivity disorder is frequently reported in individuals with Down
syndrome, with considerable variation in the expression and severity of the symptoms …