GnRH replacement rescues cognition in Down syndrome
M Manfredi-Lozano, V Leysen, M Adamo, I Paiva… - Science, 2022 - science.org
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …
[HTML][HTML] Astrocytes in Down syndrome across the lifespan
B Ponroy Bally, KK Murai - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Down Syndrome (DS) is the most common genetic cause of intellectual disability in which
delays and impairments in brain development and function lead to neurological and …
delays and impairments in brain development and function lead to neurological and …
[HTML][HTML] Craniofacial morphology in down syndrome: a systematic review and meta-analysis
A Vicente, LA Bravo-González, A López-Romero… - Scientific Reports, 2020 - nature.com
The aim of this study was to evaluate the craniofacial cephalometric characteristics of
individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic …
individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic …
[HTML][HTML] Cognitive profiles in children and adolescents with Down syndrome
S Onnivello, F Pulina, C Locatelli, C Marcolin… - Scientific Reports, 2022 - nature.com
The Down syndrome (DS) phenotype is usually characterized by relative strengths in non-
verbal skills and deficits in verbal processing, but high interindividual variability has been …
verbal skills and deficits in verbal processing, but high interindividual variability has been …
[HTML][HTML] Early alterations in cortical and cerebellar regional brain growth in Down Syndrome: An in vivo fetal and neonatal MRI assessment
PA Patkee, AA Baburamani, V Kyriakopoulou… - NeuroImage: Clinical, 2020 - Elsevier
Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide
spectrum of neurodevelopmental outcomes. At present, the relationship between structural …
spectrum of neurodevelopmental outcomes. At present, the relationship between structural …
[HTML][HTML] Competition between proton transfer and intermolecular Coulombic decay in water
Intermolecular Coulombic decay (ICD) is a ubiquitous relaxation channel of electronically
excited states in weakly bound systems, ranging from dimers to liquids. As it is driven by …
excited states in weakly bound systems, ranging from dimers to liquids. As it is driven by …
[HTML][HTML] Down syndrome is an oxidative phosphorylation disorder
MP Bayona-Bafaluy, N Garrido-Pérez, P Meade… - Redox Biology, 2021 - Elsevier
Down syndrome is the most common genomic disorder of intellectual disability and is
caused by trisomy of chromosome 21. Several genes in this chromosome repress …
caused by trisomy of chromosome 21. Several genes in this chromosome repress …
[HTML][HTML] Assessment of radial glia in the frontal lobe of fetuses with Down syndrome
Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated
with deviations in cortical development evidenced by simplified gyral appearance and …
with deviations in cortical development evidenced by simplified gyral appearance and …
[HTML][HTML] The role of oxidative stress in trisomy 21 phenotype
A Buczyńska, I Sidorkiewicz, AJ Krętowski… - Cellular and Molecular …, 2023 - Springer
Extensive research has been conducted to gain a deeper understanding of the deregulated
metabolic pathways in the development of trisomy 21 (T21) or Down syndrome. This …
metabolic pathways in the development of trisomy 21 (T21) or Down syndrome. This …
[HTML][HTML] Gestational age is related to symptoms of attention-deficit/hyperactivity disorder in late-preterm to full-term children and adolescents with down syndrome
L del Hoyo Soriano, T Rosser, D Hamilton, T Wood… - Scientific Reports, 2020 - nature.com
Attention-deficit/hyperactivity disorder is frequently reported in individuals with Down
syndrome, with considerable variation in the expression and severity of the symptoms …
syndrome, with considerable variation in the expression and severity of the symptoms …