Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Polymeric tissue adhesives provide versatile materials for wound management and are
widely used in a variety of medical settings ranging from minor to life-threatening tissue …

Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

Cell migration on two-dimensional substrates is typically characterized by lamellipodia at the
leading edge, mature focal adhesions and spread morphologies. These observations result …

Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes
in extracellular matrix (ECM) mechanics contribute to cancer development,, and increased …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

The extracellular matrix mechanical properties regulate processes in development, cancer,
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …